GDC-0349

• CAT Number: I000774
• CAS Number: 1207360-89-1
• Molecular Formula: C₂₄H₃₂N₆O₃
• Molecular Weight: 452.55
• Purity: ≥95%
• Target: mTOR
• Solubility: DMSO 90 mg/ml
• Storage: 3 years -20℃ powder
• IC50: 3.8 nM
• IUPAC Name: 1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea
• InChI: InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1
• InChIKey: RGJOJUGRHPQXGF-INIZCTEOSA-N
• SMILES: CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOCC5C

GDC-0349 (Cat.No:I000774) is a small molecule inhibitor that targets the fibroblast growth factor receptor (FGFR) signaling pathway. It has shown promising anticancer activity in preclinical studies by inhibiting FGFR-mediated cell growth and survival. GDC-0349 holds potential as a targeted therapy for FGFR-driven cancers and is being evaluated in ongoing research and clinical trials.

Reference

1:Autophagy induction contributes to GDC-0349 resistance in head and neck squamous cell carcinoma (HNSCC) cells. Zhou Y, Peng Y, Tang H, He X, Wang Z, Hu D, Zhou X.Biochem Biophys Res Commun. 2016 Aug 19;477(2):174-80. doi: 10.1016/j.bbrc.2016.06.039. Epub 2016 Jun 10. PMID: 27291151 2:Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. Pei Z, Blackwood E, Liu L, Malek S, Belvin M, Koehler MF, Ortwine DF, Chen H, Cohen F, Kenny JR, Bergeron P, Lau K, Ly C, Zhao X, Estrada AA, Truong T, Epler JA, Nonomiya J, Trinh L, Sideris S, Lesnick J, Bao L, Vijapurkar U, Mukadam S, Tay S, Deshmukh G, Chen YH, Ding X, Friedman LS, Lyssikatos JP.ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. doi: 10.1021/ml3003132. eCollection 2013 Jan 10. PMID: 24900569 Free PMC Article