Ganoderic acid A

• CAT Number: I004969
• CAS Number: 81907-62-2
• Molecular Formula: C30H44O7
• Molecular Weight: 516.67
• Purity: ≥95%
• Solubility: DMSO ≥ 29 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid
• InChI: InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1
• InChIKey: DYOKDAQBNHPJFD-JNTBEZBXSA-N
• SMILES: C[C@H](CC(=O)C[C@@H](C)C(=O)O)[C@H]1C[C@@H]([C@@]2([C@@]1(CC(=O)C3=C2[C@H](C[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)O)C)C)O

Ganoderic acid A (Cat.No:I004969) is a triterpenoid compound derived from the medicinal mushroom Ganoderma lucidum, commonly known as Reishi. It possesses various biological activities, including anti-inflammatory, antioxidant, and antitumor effects. Ganoderic acid A has shown potential in inhibiting cancer cell growth and modulating the immune system. 

Reference

1:Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method. Cao FR, Xiao BX, Wang LS, Tao X, Yan MZ, Pan RL, Liao YH, Liu XM, Chang Q.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:19-26. doi: 10.1016/j.jchromb.2017.03.009. Epub 2017 Mar 11. PMID: 28346885 2:Ganoderic Acid A Metabolites and Their Metabolic Kinetics. Cao FR, Feng L, Ye LH, Wang LS, Xiao BX, Tao X, Chang Q.Front Pharmacol. 2017 Mar 7;8:101. doi: 10.3389/fphar.2017.00101. eCollection 2017. PMID: 28326038 Free PMC Article3:Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study. Tawasri P, Ampasavate C, Tharatha S, Chiranthanut N, Teekachunhatean S.Biomed Res Int. 2016;2016:2819862. Epub 2016 Sep 25. PMID: 27747224 Free PMC Article4:Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Gill BS, Kumar S, Navgeet.Mol Biol Rep. 2016 Dec;43(12):1411-1422. Epub 2016 Sep 17. PMID: 27640015 5:Immunochromatographic strip assay for detection of bioactive Ganoderma triterpenoid, ganoderic acid A in Ganoderma lingzhi. Sakamoto S, Kikkawa N, Kohno T, Shimizu K, Tanaka H, Morimoto S.Fitoterapia. 2016 Oct;114:51-55. doi: 10.1016/j.fitote.2016.08.016. Epub 2016 Aug 26. PMID: 27575328 6:Ganoderic Acid A Targeting β-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study. Gill BS, Kumar S, Navgeet.Interdiscip Sci. 2016 Aug 22. [Epub ahead of print] PMID: 27549815 7:Detection of Ganoderic Acid A in Ganoderma lingzhi by an Indirect Competitive Enzyme-Linked Immunosorbent Assay. Sakamoto S, Kohno T, Shimizu K, Tanaka H, Morimoto S.Planta Med. 2016 May;82(8):747-51. doi: 10.1055/s-0042-104202. Epub 2016 Apr 19. PMID: 27093250 8:[Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells]. Shao J, Li Z, Jiao G, Sun G, Zhou Z.Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35(5):619-24. Chinese. PMID: 26018252 9:Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. Yajima Y, Miyazaki M, Okita N, Hoshino T.Int J Med Mushrooms. 2013;15(2):175-82. PMID: 23557369 10:Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. Yao X, Li G, Xu H, Lü C.Planta Med. 2012 Nov;78(16):1740-8. doi: 10.1055/s-0032-1315303. Epub 2012 Sep 7. PMID: 22961117