Ganciclovir

• CAT Number: A001164
• CAS Number: 82410-32-0
• Molecular Formula: C₉H₁₃N₅O₄
• Molecular Weight: 255.23
• Purity: ≥95%
• Target: HSV
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder
• InChI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
• InChIKey: IRSCQMHQWWYFCW-UHFFFAOYSA-N
• SMILES: C1=NC2=C(N1COC(CO)CO)NC(=NC2=O)N

Ganciclovir (INN) is an antiviral medication used to treat or prevent cytomegalovirus (CMV) infections. Ganciclovir is a synthetic analogue of 2′-deoxy-guanosine. It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during infection. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells than uninfected cells. A prodrug form with improved oral bioavailability (valganciclovir) has also been developed.

Reference

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