GalliuM Maltolate

• CAT Number: M134327
• CAS Number: 108560-70-9
• Molecular Formula: C18H15GaO9
• Molecular Weight: 445.032
• Purity: ≥95%
• Target: ribonucleoside-diphosphate reductase inhibitor
• Storage: -20°C
• IUPAC Name: gallium;2-methyl-4-oxopyran-3-olate
• InChI: InChI=1S/3C6H6O3.Ga/c3*1-4-6(8)5(7)2-3-9-4;/h3*2-3,8H,1H3;/q;;;+3/p-3
• InChIKey: ASYYOZSDALANRF-UHFFFAOYSA-K
• SMILES: CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].[Ga+3]

Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor potentially for the treatment of prostate cancer

Reference

1:Corrigendum to: /In vitro antimicrobial activity of gallium maltolate against virulent Rhodococcus equi / [Veterinary Microbiology 146 (2010) 175-178]. Coleman M, Kuskie K, Liu M, Chaffin K, Libal M, Giguère S, Bernstein L, Cohen N.Vet Microbiol. 2016 Nov 15;195:165. doi: 10.1016/j.vetmic.2016.09.004. Epub 2016 Oct 6. No abstract available. PMID: 27771063 2:Serum and tissue concentrations of gallium after oral administration of gallium nitrate and gallium maltolate to neonatal calves. Monk CS, Sweeney RW, Bernstein LR, Fecteau ME.Am J Vet Res. 2016 Feb;77(2):151-5. doi: 10.2460/ajvr.77.2.151. PMID: 27027708 3:Gallium maltolate as an alternative to macrolides for treatment of presumed Rhodococcus equi pneumonia in foals. Cohen ND, Slovis NM, Giguère S, Baker S, Chaffin MK, Bernstein LR.J Vet Intern Med. 2015 May-Jun;29(3):932-9. doi: 10.1111/jvim.12595. Epub 2015 Apr 13. PMID: 25868480 Free PMC Article4:Gallium maltolate inhibits human cutaneous T-cell lymphoma tumor development in mice. Wu X, Wang TW, Lessmann GM, Saleh J, Liu X, Chitambar CR, Hwang ST.J Invest Dermatol. 2015 Mar;135(3):877-84. doi: 10.1038/jid.2014.476. Epub 2014 Nov 5. PMID: 25371972 Free Article5:Comparison of the antimicrobial activities of gallium nitrate and gallium maltolate against Mycobacterium avium subsp. paratuberculosis in vitro. Fecteau ME, Aceto HW, Bernstein LR, Sweeney RW.Vet J. 2014 Oct;202(1):195-7. doi: 10.1016/j.tvjl.2014.06.023. Epub 2014 Jul 3. PMID: 25155307 6:In vitro susceptibility of equine-obtained isolates of Corynebacterium pseudotuberculosis to gallium maltolate and 20 other antimicrobial agents. Norman TE, Batista M, Lawhon SD, Zhang S, Kuskie KR, Swinford AK, Bernstein LR, Cohen ND.J Clin Microbiol. 2014 Jul;52(7):2684-5. doi: 10.1128/JCM.01252-14. Epub 2014 May 14. PMID: 24829243 Free PMC Article7:Efficacy of gallium maltolate against Lawsonia intracellularis infection in a rabbit model. Sampieri F, Allen AL, Alcorn J, Clark CR, Vannucci FA, Pusterla N, Mapes SM, Ball KR, Dowling PM, Thompson J, Bernstein LR, Gebhart CJ, Hamilton DL.J Vet Pharmacol Ther. 2014 Dec;37(6):571-8. doi: 10.1111/jvp.12132. Epub 2014 Apr 15. PMID: 24730377 8:Pharmacokinetics of gallium maltolate in Lawsonia intracellularis-infected and uninfected rabbits. Sampieri F, Alcorn J, Allen AL, Clark CR, Vannucci FA, Pusterla N, Mapes S, Ball KR, Dowling PM, Thompson J, Bernstein LR, Gebhart CJ, Hamilton DL.J Vet Pharmacol Ther. 2014 Oct;37(5):486-99. doi: 10.1111/jvp.12114. Epub 2014 Mar 15. PMID: 24628462 9:Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics. Pollina GF, Pepe M, Dean A, Di Marco V, Marton D.J Vet Pharmacol Ther. 2013 Oct;36(5):456-61. PMID: 23980593 10:Synchrotron X-ray fluorescence microscopy of gallium in bladder tissue following gallium maltolate administration during urinary tract infection. Ball KR, Sampieri F, Chirino M, Hamilton DL, Blyth RI, Sham TK, Dowling PM, Thompson J.Antimicrob Agents Chemother. 2013 Nov;57(11):5197-201. doi: 10.1128/AAC.00616-13. Epub 2013 Jul 22. PMID: 23877680 Free PMC Article