G-Protein antagonist peptide TFA

• CAT Number: I045858
• Molecular Formula: C59H65F3N12O11S
• Molecular Weight: 1207.28
• Purity: ≥95%
• IUPAC Name: (2S)-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanediamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C57H64N12O9S.C2HF3O2/c1-79-24-23-42(51(59)72)64-55(76)46(26-33-29-60-39-16-8-5-13-36(33)39)69-57(78)48(28-35-31-62-41-18-10-7-15-38(35)41)68-54(75)45(25-32-11-3-2-4-12-32)66-56(77)47(27-34-30-61-40-17-9-6-14-37(34)40)67-53(74)44(19-21-49(58)70)65-52(73)43-20-22-50(71)63-43;3-2(4,5)1(6)7/h2-18,29-31,42-48,60-62H,19-28H2,1H3,(H2,58,70)(H2,59,72)(H,63,71)(H,64,76)(H,65,73)(H,66,77)(H,67,74)(H,68,75)(H,69,78);(H,6,7)/t42-,43-,44-,45-,46+,47+,48+;/m0./s1
• InChIKey: ZKMDXZWWHDBKTN-KTYXIFTBSA-N
• SMILES: CSCC[C@@H](C(=O)N)NC(=O)[C@@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@@H](CC6=CNC7=CC=CC=C76)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]8CCC(=O)N8.C(=O)(C(F)(F)F)O

G-Protein antagonist peptide TFA（Cat No.:I045858）is a synthetic peptide that selectively disrupts G-protein–coupled receptor (GPCR) signaling by interfering with the interaction between activated receptors and their G-proteins. This inhibition allows researchers to dissect GPCR-mediated pathways and study receptor-specific signaling mechanisms. The trifluoroacetate (TFA) salt form enhances peptide stability and experimental reliability. Widely used in pharmacology, neuroscience, and cell biology, this antagonist peptide serves as a valuable tool for investigating receptor regulation, intracellular signaling cascades, and the development of therapeutic strategies targeting GPCR-driven diseases.