For research use only. Not for therapeutic Use.
FT206（Cat No.:I044573）is a potent, selective small-molecule inhibitor targeting USP28 and USP25, two deubiquitinases involved in cancer progression. By blocking these enzymes, FT206 promotes the degradation of oncoproteins such as c-Myc and ΔNp63, critical for tumor cell survival, particularly in squamous cell carcinomas. FT206 exhibits strong anti-tumor activity in preclinical models with favorable pharmacokinetics and low toxicity. Its dual inhibition mechanism disrupts protein homeostasis in cancer cells, offering a promising therapeutic strategy for targeting ubiquitin-proteasome pathway dysregulation. FT206 is a valuable tool for oncology and protein degradation research.
| CAS Number | 2278274-34-1 |
| Synonyms | 3-amino-N-[(2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide |
| Molecular Formula | C25H29N5OS |
| Purity | ≥95% |
| IUPAC Name | 3-amino-N-[(2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide |
| InChI | InChI=1S/C25H29N5OS/c1-14-2-9-21-22(26)23(32-25(21)27-14)24(31)29-17-5-3-16-11-20(8-4-15(16)10-17)30-12-18-6-7-19(13-30)28-18/h2,4,8-9,11,17-19,28H,3,5-7,10,12-13,26H2,1H3,(H,29,31)/t17-,18?,19?/m0/s1 |
| InChIKey | UZKKSCQGVUDMFY-VIQWUECVSA-N |
| SMILES | CC1=NC2=C(C=C1)C(=C(S2)C(=O)N[C@H]3CCC4=C(C3)C=CC(=C4)N5CC6CCC(C5)N6)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
