Fostedil

• CAT Number: I006854
• CAS Number: 75889-62-2
• Molecular Formula: C18H20NO3PS
• Molecular Weight: 361.39
• Purity: ≥95%
• Target: calcium channel antagonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: 2-[4-(diethoxyphosphorylmethyl)phenyl]-1,3-benzothiazole
• InChI: InChI=1S/C18H20NO3PS/c1-3-21-23(20,22-4-2)13-14-9-11-15(12-10-14)18-19-16-7-5-6-8-17(16)24-18/h5-12H,3-4,13H2,1-2H3
• InChIKey: FVYRUSCZCWSFLT-UHFFFAOYSA-N
• SMILES: CCOP(=O)(CC1=CC=C(C=C1)C2=NC3=CC=CC=C3S2)OCC

Fostedil (Cat.No:I006854), also known as KB-944, is a calcium channel antagonist potentially for the treatment of angina pectoris. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardial blood flow during partial coronary artery occlusion despite a reduction in aortic pressure. In a model of total coronary artery occlusion.

Reference

1:Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil. Tchani G, Baziard-Mouysset G, Stigliani JL, Payard M, Bonnafous R, Tisne-Versailles J.Pharm Acta Helv. 1994 Jan;68(3):173-9. PMID: 8121926 2:Chromosome and xanthone derivatives related to Fostedil. Chiarini A, Valenti P, Fabbri G, da Re P.Acta Pharm Suec. 1987;24(5):257-62. No abstract available. PMID: 3450191 3:Ambulatory monitoring and exercise testing in the evaluation of a new long-acting calcium ion antagonist KB-944 (Fostedil) for the treatment of exertional angina pectoris. Khurmi NS, Bowles MJ, O/’Hara MJ, Lahiri A, Raftery EB.Int J Cardiol. 1985 Nov;9(3):289-302. PMID: 3902675 4:Pharmacokinetics of fostedil, a new calcium antagonist, in beagle dogs following oral and intravenous administration. Thomas EW, Bopp BA.J Pharm Sci. 1984 Oct;73(10):1400-3. PMID: 6542139 5:Cardiac electrophysiologic actions of KB-944 (Fostedil), a new calcium antagonist, in the anesthetized dog. Patterson E, Montgomery DG, Lynch JJ, Lucchesi BR.J Pharmacol Exp Ther. 1984 Sep;230(3):632-40. PMID: 6540806 6:High-performance liquid chromatographic determination of a new calcium antagonist, fostedil, in plasma and urine using fluorescence detection. Thomas EW.J Chromatogr. 1984 Jan 13;305(1):233-8. No abstract available. PMID: 6538578