Forasartan

• CAT Number: M097773
• CAS Number: 145216-43-9
• Molecular Formula: C23H28N8
• Molecular Weight: 416.533
• Purity: ≥95%
• Target: Angiotensin II Receptor Antagonist
• Storage: Store at -20C
• IUPAC Name: 5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine
• InChI: InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)
• InChIKey: YONOBYIBNBCDSJ-UHFFFAOYSA-N
• SMILES: CCCCC1=NN(C(=N1)CCCC)CC2=CN=C(C=C2)C3=CC=CC=C3C4=NNN=N4

Forasartan is a nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex.

Reference

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