Folinic acid

• CAT Number: I000020
• CAS Number: 58-05-9
• Molecular Formula: C20H23N7O7
• Molecular Weight: 473.44
• Purity: ≥95%
• Target: Antifolate
• Solubility: 10mM in water
• Storage: 2–8 °C
• IUPAC Name: (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
• InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
• InChIKey: VVIAGPKUTFNRDU-ABLWVSNPSA-N
• SMILES: C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Leucovorin (Cat No.: I000020) is a special form of reduced folic acid. Giving high-dose folinic acid intervention to children with CFD can improve their neurological and developmental abnormalities. Folinic acid is a type of biological folic acid that is often administered with methotrexate (MTX) as a rescue agent to reduce MTX-induced toxicity.

Reference

[1]. Goldman, I.D. and L.H. Matherly, Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. NCI Monogr, 1987(5): p. 17-26.

[2]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.