Fmoc-Tyr(tBu)-OH

• CAT Number: L014977
• CAS Number: 71989-38-3
• Molecular Formula: C28H29NO5
• Molecular Weight: 459.50
• Purity: ≥95%
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid
• InChI: InChI=1S/C28H29NO5/c1-28(2,3)34-19-14-12-18(13-15-19)16-25(26(30)31)29-27(32)33-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,29,32)(H,30,31)/t25-/m0/s1
• InChIKey: JAUKCFULLJFBFN-VWLOTQADSA-N
• SMILES: CC(C)(C)OC1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-Tyr(tBu)-OH（Cat No.:L014977）is a protected form of the amino acid tyrosine used in Fmoc-based solid-phase peptide synthesis (SPPS). It carries an Fmoc (9-fluorenylmethyloxycarbonyl) group on the α-amino group and a tert-butyl (tBu) group on the phenolic hydroxyl of the tyrosine side chain. This dual protection prevents unwanted side reactions, ensuring selective peptide bond formation. The Fmoc group is removed under basic conditions, while the tBu group is cleaved under acidic conditions during final deprotection. Fmoc-Tyr(tBu)-OH enables efficient incorporation of tyrosine into peptides with high purity and stability.