MM-419447 (Linaclotide Metabolite)

  • CAT Number: P000427
  • Molecular Formula: C50H70N14O19S6
  • Molecular Weight: 1362.3
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">MM-419447 &nbsp;&nbsp;is a Linaclotide metabolite, which is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.</span></span></span>

Catalog Number P000427
Synonyms

MM-419447 (Linaclotide Metabolite); CCEYCCNPACTGC(Cys1&Cys6,Cys2&Cys10,Cys5&Cys13 bridge)

Molecular Formula

C50H70N14O19S6

Purity 95%
Reference

<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">1.Chey, William D., et al. &quot;Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">American Journal of Gastroenterology</i>&nbsp;107.11 (2012): 1702-1712.<br />
2.Rao, Satish, et al. &quot;A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">The American journal of gastroenterology</i>&nbsp;107.11 (2012): 1714.<br />
3.Brierley, Stuart M. &quot;Guanylate cyclase-C receptor activation: unexpected biology.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Current opinion in pharmacology</i>&nbsp;12.6 (2012): 632-640.</span></span></span>

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