MM-419447 (Linaclotide Metabolite)

• CAT Number: P000427
• Molecular Formula: C50H70N14O19S6
• Molecular Weight: 1362.3
• Purity: ≥95%
• Synonyms: MM-419447 (Linaclotide Metabolite); CCEYCCNPACTGC(Cys1&Cys6,Cys2&Cys10,Cys5&Cys13 bridge)

MM-419447   is a Linaclotide metabolite, which is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.

Reference

1.Chey, William D., et al. "Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety." American Journal of Gastroenterology 107.11 (2012): 1702-1712.
2.Rao, Satish, et al. "A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation." The American journal of gastroenterology 107.11 (2012): 1714.
3.Brierley, Stuart M. "Guanylate cyclase-C receptor activation: unexpected biology." Current opinion in pharmacology 12.6 (2012): 632-640.