Fmoc-NH-ethyl-SS-propionic acid

• CAT Number: I016120
• CAS Number: 864235-83-6
• Molecular Formula: C20H21NO4S2
• Molecular Weight: 403.52
• Purity: ≥95%
• Synonyms: 3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyldisulfanyl]propanoic acid
• InChI: InChI=1S/C20H21NO4S2/c22-19(23)9-11-26-27-12-10-21-20(24)25-13-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,18H,9-13H2,(H,21,24)(H,22,23)
• InChIKey: FXHUKQIBGGQHPZ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCSSCCC(=O)O

Fmoc-NH-ethyl-SS-propionic acid（Cat No.:I016120）is a protected, cleavable linker reagent tailored for peptide synthesis and bioconjugation. It contains an Fmoc-protected amine group suitable for solid-phase peptide synthesis (SPPS), a disulfide (SS) bond that provides redox-sensitive cleavage, and a propionic acid moiety enabling further coupling reactions. The ethyl spacer offers flexibility and reduces steric hindrance in conjugation strategies. This reagent is especially valuable for designing thiol-cleavable linkers in drug delivery systems, peptide–drug conjugates, and controlled release studies, making it a versatile tool in chemical biology and medicinal chemistry.