FMF-04-159-2

• CAT Number: I019007
• CAS Number: 2364489-81-4
• Molecular Formula: C₂₈H₃₀Cl₃N₇O₅S
• Molecular Weight: 683.01
• Purity: ≥95%
• IUPAC Name: N-[1-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]sulfonylpiperidin-4-yl]-4-[(2,4,6-trichlorobenzoyl)amino]-1H-pyrazole-5-carboxamide
• InChI: InChI=1S/C28H30Cl3N7O5S/c1-37(2)10-4-7-24(39)33-19-5-3-6-20(15-19)44(42,43)38-11-8-18(9-12-38)34-28(41)26-23(16-32-36-26)35-27(40)25-21(30)13-17(29)14-22(25)31/h3-7,13-16,18H,8-12H2,1-2H3,(H,32,36)(H,33,39)(H,34,41)(H,35,40)/b7-4+
• InChIKey: HZPYSAHDRSBARR-QPJJXVBHSA-N
• SMILES: CN(C)CC=CC(=O)NC1=CC(=CC=C1)S(=O)(=O)N2CCC(CC2)NC(=O)C3=C(C=NN3)NC(=O)C4=C(C=C(C=C4Cl)Cl)Cl

FMF-04-159-2（Cat No.:I019007） is a potent inhibitor of cyclin-dependent kinase 14 (CDK14), acting through a covalent mechanism. It effectively inhibits the activity of CDK14 with an IC50 value of 39.6 nM in a NanoBRET assay. Additionally, it displays inhibitory activity against CDK2 with an IC50 value of 256 nM in the same assay. The selective inhibition of CDK14 by FMF-04-159-2 highlights its potential as a therapeutic agent for targeting CDK14-related cellular processes and diseases.

Reference

[1]. Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.