Fluphenazine

• CAT Number: I006820
• CAS Number: 69-23-8
• Molecular Formula: C22H26F3N3OS
• Molecular Weight: 437.5215
• Purity: ≥95%
• Synonyms: Fluphenazine, Triflumethazine, Fluorophenazine, Fluorfenazine, Fluorphenazine, Siqualine;2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term

Fluphenazine, sold under the brand names Prolixin among others, is a antipsychotic medication. It is used in the treatment of chronic psychoses such as schizophrenia. Fluphenazine exerts its actions by blocking postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia. It is given by mouth, injection into a muscle, or just under the skin.

Reference

1:Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food-drug interaction by spectroscopic techniques. Jing JJ, Liu B, Wang X, Wang X, He LL, Guo XY, Xu ML, Li QY, Gao B, Dong BY.Luminescence. 2017 Apr 4. doi: 10.1002/bio.3291. [Epub ahead of print] PMID: 28374530 2:Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death. Klutzny S, Lesche R, Keck M, Kaulfuss S, Schlicker A, Christian S, Sperl C, Neuhaus R, Mowat J, Steckel M, Riefke B, Prechtl S, Parczyk K, Steigemann P.Cell Death Dis. 2017 Mar 30;8(3):e2709. doi: 10.1038/cddis.2017.130. PMID: 28358364 Free PMC Article3:The Effect of Fluphenazine and Thioridazine on Toxoplasma gondii In Vivo. Saraei M, Ghaderi Y, Mosavi T, Shahnazi M, Nassiri-Asl M, Jahanihashemi H.Iran J Parasitol. 2016 Apr-Jun;11(2):226-231. PMID: 28096857 Free PMC Article4:Highly Halaven-resistant KBV20C Cancer Cells Can Be Sensitized by Co-treatment with Fluphenazine. Cheon JH, Lee BM, Kim HS, Yoon S.Anticancer Res. 2016 Nov;36(11):5867-5874. PMID: 27793910 5:Fluphenazine (oral) versus atypical antipsychotics for schizophrenia. Sampford JR, Sampson S, Li BG, Zhao S, Xia J, Furtado VA.Cochrane Database Syst Rev. 2016 Jul 2;7:CD010832. doi: 10.1002/14651858.CD010832.pub2. Review. PMID: 27370402 6:Forced Degradation Behaviour of Fluphenazine Hydrochloride by LC and Characterization of its Oxidative Degradation Product by LC-MS/MS. Thummar KN, Ghava DJ, Mistry A, Vachhani A, Sheth NR.Sci Pharm. 2014 Dec 22;83(2):297-309. doi: 10.3797/scipharm.1411-04. Print 2015 Apr-Jun. PMID: 26839816 Free PMC Article7:Harpagophytum Procumbens Ethyl Acetate Fraction Reduces Fluphenazine-Induced Vacuous Chewing Movements and Oxidative Stress in Rat Brain. Schaffer LF, de Freitas CM, Chiapinotto Ceretta AP, Peroza LR, de Moraes Reis E, Krum BN, Busanello A, Boligon AA, Sudati JH, Fachinetto R, Wagner C.Neurochem Res. 2016 May;41(5):1170-84. doi: 10.1007/s11064-015-1811-y. Epub 2016 Jan 6. PMID: 26732278 8:Quantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Slawson MH, Johnson-Davis KL.Methods Mol Biol. 2016;1383:49-57. doi: 10.1007/978-1-4939-3252-8_6. PMID: 26660173 9:The effect of fluphenazine decanoate on glucocorticoid production, reproductive cyclicity, and the behavioral stress response in the Persian onager (Equus hemionus onager). Wagman JD, Wolfe BA, Schook MW.Zoo Biol. 2015 Nov;34(6):525-34. doi: 10.1002/zoo.21250. Epub 2015 Oct 22. PMID: 26491959 10:Electrocatalysis of NADH oxidation using electrochemically activated fluphenazine on carbon nanotube electrode. Sobczak A, Rębiś T, Milczarek G.Bioelectrochemistry. 2015 Dec;106(Pt B):308-15. doi: 10.1016/j.bioelechem.2015.07.002. Epub 2015 Jul 13. PMID: 26211441