Fluasterone

• CAT Number: R012250
• CAS Number: 112859-71-9
• Molecular Formula: C₁₉H₂₇FO
• Molecular Weight: 290.42
• Purity: ≥95%
• Storage: 3 years -20C powder

Fluasterone, also known as HE2500, is an NF-κB activation inhibitor potentially for the treatment of metabolic syndrome.

Reference

1:Pharmacokinetic and tissue distribution study of [14C]fluasterone in male Beagle dogs following intravenous, oral and subcutaneous dosing routes. Lindeblad MO, Bauer KS, Zakharov AD, Hill JM, Green JS, Thomas BF, Schwartz A, Kapetanovic IM, Lyubimov A.Chem Biol Interact. 2010 Jan 27;183(2):317-26. doi: 10.1016/j.cbi.2009.10.004. Epub 2009 Dec 6. PMID: 19836365 2:Identification of [14C]fluasterone metabolites in urine and feces collected from dogs after subcutaneous and oral administration of [14C]fluasterone. Burgess JP, Green JS, Hill JM, Zhan Q, Lindeblad M, Lyubimov A, Kapetanovic IM, Schwartz A, Thomas BF.Drug Metab Dispos. 2009 May;37(5):1089-97. doi: 10.1124/dmd.108.023614. Epub 2009 Feb 5. PMID: 19196848 Free PMC Article3:Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone. McCormick DL, Johnson WD, Kozub NM, Rao KV, Lubet RA, Steele VE, Bosland MC.Carcinogenesis. 2007 Feb;28(2):398-403. Epub 2006 Sep 3. PMID: 16952912 4:Solubilization of Fluasterone in cosolvent/cyclodextrin combinations. He Y, Li P, Yalkowsky SH.Int J Pharm. 2003 Oct 2;264(1-2):25-34. PMID: 12972333 5:Solubilization of fluasterone. Zhao L, Li P, Yalkowsky SH.J Pharm Sci. 1999 Oct;88(10):967-9. PMID: 10514340