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FLT3-IN-2

FLT3-IN-2

  • CAT Number: I005494
  • CAS Number: 923562-23-6
  • Molecular Formula: C21H16ClF3N4
  • Molecular Weight: 416.83
  • Purity: ≥95%
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FLT3-IN-2 is a FLT3 inhibitor with IC50 of ＜ 1 μM, detailed information refer to WO 2012158957 A2 and WO 2007013896.

Catalog Number I005494
CAS Number 923562-23-6
Molecular Formula

C21H16ClF3N4

Purity 95%
Target FLT3
Solubility DMSO: ≥ 30 mg/mL
Storage Store at -20°C
IC50 IC50 of ＜ 1 μM
InChI InChI=1S/C21H16ClF3N4/c22-17-8-18-15(11-28-20(18)29-12-17)7-14-3-6-19(27-10-14)26-9-13-1-4-16(5-2-13)21(23,24)25/h1-6,8,10-12H,7,9H2,(H,26,27)(H,28,29)
InChIKey MFXPJGJSKHZZGC-UHFFFAOYSA-N
SMILES FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=C1)(F)F
Reference

<p>
[1]. Zhang, Chao, et al. Kinase modulation for the treatment of leukemias. From PCT Int. Appl. (2012), WO 2012158957 A2 20121122.&nbsp;
</p>
<p>
[2]. Zhang Chao, et al. 7-Azaindole derivatives and their preparation, pharmaceutical compositions and use for modulating c-kit and c-fms activity. From PCT Int. Appl. (2007), WO 2007013896 A2 20070201.
</p>

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