Firocoxib

• CAT Number: I002443
• CAS Number: 189954-96-9
• Molecular Formula: C17H20O5S
• Molecular Weight: 336.4
• Purity: ≥95%
• Target: COX
• Solubility: DMSO: ≥ 52 mg/mL
• Storage: Store at -20°C
• IC50: 0.13 uM
• IUPAC Name: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
• InChI: InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
• InChIKey: FULAPETWGIGNMT-UHFFFAOYSA-N
• SMILES: CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)S(=O)(=O)C)C

Firocoxib (CAT: I002443) is a nonsteroidal anti-inflammatory drug (NSAID) belonging to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It is primarily used in veterinary medicine for the treatment of pain and inflammation associated with musculoskeletal disorders in dogs and horses. Firocoxib works by selectively inhibiting COX-2, an enzyme involved in the production of inflammatory mediators called prostaglandins. By targeting COX-2, firocoxib helps to reduce pain, inflammation, and swelling. This medication is commonly prescribed for conditions such as osteoarthritis and postoperative pain in animals. It provides an effective and targeted approach to managing pain and improving the quality of life in veterinary patients.

Reference

1:Pharmacokinetics of firocoxib after intravenous administration of multiple consecutive doses in neonatal foals. Wilson KE, Davis JL, Crisman MV, Kvaternick V, Zarabadipour C, Cheramie H, Hodgson DR.J Vet Pharmacol Ther. 2017 Apr 29. doi: 10.1111/jvp.12410. [Epub ahead of print] PMID: 28456000
2:Effects of Firocoxib, Flunixin Meglumine, and Phenylbutazone on Platelet Function and Thromboxane Synthesis in Healthy Horses. Burkett BN, Thomason JM, Hurdle HM, Wills RW, Fontenot RL.Vet Surg. 2016 Nov;45(8):1087-1094. doi: 10.1111/vsu.12567. Epub 2016 Oct 12. PMID: 27731498
3:Analgesic efficacy of oral firocoxib in ovariohysterectomized cats. Phuwapattanachart P, Thengchaisri N.J Vet Sci. 2016 Aug 10. [Epub ahead of print] PMID: 27515266
4:Effect of firocoxib on cyclooxygenase 2, microsomal prostaglandin E2 synthase 1, and cytosolic phospholipase A2 gene expression in equine mononuclear cells. Barton MH, Darden JE, Clifton S, Vandenplas M.Am J Vet Res. 2015 Dec;76(12):1051-7. doi: 10.2460/ajvr.76.12.1051. PMID: 26618729
5:Analgesic Efficacy of Firocoxib, a Selective Inhibitor of Cyclooxygenase 2, in a Mouse Model of Incisional Pain. Reddyjarugu B, Pavek T, Southard T, Barry J, Singh B.J Am Assoc Lab Anim Sci. 2015 Jul;54(4):405-10. PMID: 26224441 Free PMC Article
6:Disposition of firocoxib in late pregnant and early postpartum mares. Giguère S, Macpherson ML, Benson SM, Cox S, McNaughten JW, Pozor MA.J Vet Pharmacol Ther. 2016 Apr;39(2):196-8. doi: 10.1111/jvp.12253. Epub 2015 Jul 23. PMID: 26202842
7:The effects of firocoxib on cautery disbudding pain and stress responses in preweaned dairy calves. Stock ML, Millman ST, Barth LA, Van Engen NK, Hsu WH, Wang C, Gehring R, Parsons RL, Coetzee JF.J Dairy Sci. 2015 Sep;98(9):6058-69. doi: 10.3168/jds.2014-8877. Epub 2015 Jul 2. PMID: 26142860
8:Effect of flunixin meglumine and firocoxib on ex vivo cyclooxygenase activity in horses undergoing elective surgery. Duz M, Parkin TD, Cullander RM, Marshall JF.Am J Vet Res. 2015 Mar;76(3):208-15. doi: 10.2460/ajvr.76.3.208. PMID: 25710756
9:Combination of radiation therapy and firocoxib for the treatment of canine nasal carcinoma. Cancedda S, Sabattini S, Bettini G, Leone VF, Laganga P, Rossi F, Terragni R, Gnudi G, Vignoli M.Vet Radiol Ultrasound. 2015 May-Jun;56(3):335-43. doi: 10.1111/vru.12246. Epub 2015 Feb 21. PMID: 25703137
10:Pharmacokinetics and metabolism study of firocoxib in camels after intravenous administration by using high-resolution bench-top orbitrap mass spectrometry. Wasfi IA, Saeed HM, Agha BA, Kamel AM, Al Biriki NA, Al Neaimi KM, Al Ali WA, Sultan SM.J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:17-23. doi: 10.1016/j.jchromb.2014.10.021. Epub 2014 Oct 24. PMID: 25463193