FIPI

• CAT Number: I005579
• CAS Number: 939055-18-2
• Molecular Formula: C23H24FN5O2
• Molecular Weight: 421.5
• Purity: ≥95%
• Target: Phospholipase
• Solubility: DMSO: ≤ 14.67 mg/mL
• Storage: Store at 4℃
• IC50: 20 nM (PLD2)
• IUPAC Name: 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide
• InChI: InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31)
• InChIKey: LHABRXRGDLASIH-UHFFFAOYSA-N
• SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F

FIPI (Cat.No:I005579) is an inhibitor of phosphatidylinositol 4-phosphate 5-kinase (PIPK) enzymes. It selectively targets PIPK isoforms, disrupting the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2). This modulation of PIP2 levels affects various cellular processes, including intracellular signaling and vesicle trafficking. FIPI is utilized in research to investigate PIPK-mediated signaling pathways and their role in disease progression.

Reference

1:Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N/’-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL.Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12. PMID: 21994240 Free PMC Article2:5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Su W, Yeku O, Olepu S, Genna A, Park JS, Ren H, Du G, Gelb MH, Morris AJ, Frohman MA.Mol Pharmacol. 2009 Mar;75(3):437-46. doi: 10.1124/mol.108.053298. Epub 2008 Dec 8. PMID: 19064628 Free PMC Article