Fexofenadine HCl - CAS 153439-40-8
Fexofenadine HCl (CAT: A000215) is an antihistamine medication used to relieve allergy symptoms. It is commonly used to treat conditions such as seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). Fexofenadine works by blocking the effects of histamine, a substance produced by the body during an allergic reaction. By inhibiting histamine’s action, it helps alleviate symptoms like sneezing, runny nose, itchy or watery eyes, and itching of the throat or nose.
Catalog Number: A000215
CAS Number: 153439-40-8
PubChem Substance ID:355037900
Molecular Formula: C32H39NO4 • HCl
Molecular Weight:538.1
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | MDL 16455A |
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Property
Molecular Formula: | C32H39NO4 • HCl |
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Molecular Weight | 538.1 |
Target: | Histamine Receptor |
Solubility | Soluble in DMSO > 10 mM |
Purity | ≥95% |
Storage | 3 years -20C powder |
Overview of Clinical Research | <p> Fexofenadine is a <span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”><span style=”orphans: 2; widows: 2;”>histamine H1 receptor antagonist. </span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Sanofi completed a phase III trial in Seasonal allergic rhinitis in Canada (PO) (NCT03664882) in 2019.</span></span></span></p> <ul class=”data-list__content” id=”at-a-glance_orphanStatus” style=”list-style: none; margin: 0px; padding-right: 0px; padding-left: 0px; color: rgb(51, 51, 51); font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”> <li class=”data-list__property” style=”list-style: none; zoom: 1; margin-bottom: 10px;”> </li> </ul> |
Computed Descriptor
IUPAC Name | 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid;hydrochloride |
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InChI | InChI=1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H |
InChIKey | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
SMILES | CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O.Cl |