Fenoprofen

• CAT Number: I006261
• CAS Number: 29679-58-1
• Molecular Formula: C15H14O3
• Molecular Weight: 242.27
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IUPAC Name: 2-(3-phenoxyphenyl)propanoic acid
• InChI: InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)
• InChIKey: RDJGLLICXDHJDY-UHFFFAOYSA-N
• SMILES: CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)O

Fenoprofen（Cat No.:I006261） is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief of rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen blocks the enzymes that make prostaglandins (cyclooxygenases), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, swelling, pain, and fever are reduced.

Reference

1:Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation. Farghaly DA, Aboelwafa AA, Hamza MY, Mohamed MI.AAPS PharmSciTech. 2017 Apr 20. doi: 10.1208/s12249-017-0771-8. [Epub ahead of print] PMID: 28429293 2:Microemulsion for topical delivery of fenoprofen calcium: in vitro and in vivo evaluation. Farghaly DA, Aboelwafa AA, Hamza MY, Mohamed MI.J Liposome Res. 2017 Feb 6:1-11. doi: 10.1080/08982104.2017.1281951. [Epub ahead of print] PMID: 28081643 3:Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Montero-Melendez T, Forfar RA, Cook JM, Jerman JC, Taylor DL, Perretti M.Cell Mol Life Sci. 2017 Apr;74(7):1335-1345. doi: 10.1007/s00018-016-2419-3. Epub 2016 Nov 16. PMID: 27853832 Free PMC Article4:Albumin Supplement Affects the Metabolism and Metabolism-Related Drug-Drug Interaction of Fenoprofen Enantiomers. Wang N, Wang F, Meng Y, Yang GH, Chen JW, Wang JX.Chirality. 2015 Jul;27(7):436-40. doi: 10.1002/chir.22462. Epub 2015 Jun 3. PMID: 26037509 5:A supramolecular topical gel derived from a non-steroidal anti-inflammatory drug, fenoprofen, is capable of treating skin inflammation in mice. Majumder J, Yedoti P, Dastidar P.Org Biomol Chem. 2015 Feb 28;13(8):2300-9. doi: 10.1039/c4ob02344g. PMID: 25554116 6:Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: promising insights in the treatment of chronic inflammatory diseases. Agotegaray M, Gumilar F, Boeris M, Toso R, Minetti A.Biomed Res Int. 2014;2014:505987. doi: 10.1155/2014/505987. Epub 2014 Jun 19. PMID: 25050353 Free PMC Article7:Hyphenation of ionic liquid albumin glassy carbon biosensor or protein label-free sensor with differential pulse stripping voltammetry for interaction studies of human serum albumin with fenoprofen enantiomers. Abd El-Hady D, Youssef AK.Anal Chim Acta. 2013 Apr 15;772:68-74. doi: 10.1016/j.aca.2013.02.018. Epub 2013 Feb 19. PMID: 23540249 8:Immediate release three-layered chewing gum tablets of fenoprofen calcium: preparation, optimization and bioavailability studies in healthy human volunteers. El Assassy AE, Amin MM, Abdelbary AA.Drug Dev Ind Pharm. 2012 May;38(5):603-15. doi: 10.3109/03639045.2011.620967. Epub 2011 Oct 11. PMID: 21988149 9:A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration. Wang Z, Liu C, Kang J.J Chromatogr A. 2011 Apr 1;1218(13):1775-9. doi: 10.1016/j.chroma.2011.01.081. Epub 2011 Feb 4. PMID: 21342694 10:Single dose oral fenoprofen for acute postoperative pain in adults. Traa MX, Derry S, Moore RA.Cochrane Database Syst Rev. 2011 Feb 16;(2):CD007556. doi: 10.1002/14651858.CD007556.pub2. Review. PMID: 21328296 Free PMC Article