Fenbufen

  • CAT Number: I003335
  • CAS Number: 36330-85-5
  • Molecular Formula: C16H14O3
  • Molecular Weight: 254.28
  • Purity: ≥95%
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Fenbufen(Cat No.:I003335) is a non-steroidal anti-inflammatory drug (NSAID) belonging to the propionic acid derivatives class. It is used for the relief of pain and inflammation associated with various conditions, including arthritis and musculoskeletal disorders. Fenbufen works by inhibiting the production of inflammatory substances called prostaglandins, thereby reducing pain and swelling. It is available in oral dosage forms and is typically prescribed for short-term use.

Catalog Number I003335
CAS Number 36330-85-5
Molecular Formula

C16H14O3

Purity 95%
Target COX
Solubility 10 mM in DMSO
Storage 2-8°C
IUPAC Name 4-oxo-4-(4-phenylphenyl)butanoic acid
InChI InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)
InChIKey ZPAKPRAICRBAOD-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CCC(=O)O
Reference

</br>1:Synthesis and Biological Evaluation of an (18)Fluorine-Labeled COX Inhibitor–[(18)F]Fluorooctyl Fenbufen Amide–For Imaging of Brain Tumors. Huang YC, Chang YC, Yeh CN, Yu CS.Molecules. 2016 Mar 21;21(3):387. doi: 10.3390/molecules21030387. PMID: 27007363 Free Article</br>2:Bioanalytical method development for quantification of ulifloxacin, fenbufen and felbinac in rat plasma by solid-phase extraction (SPE) and HPLC with PDA detection. Ferrone V, Carlucci M, Palumbo P, Carlucci G.J Pharm Biomed Anal. 2016 May 10;123:205-12. doi: 10.1016/j.jpba.2016.01.062. Epub 2016 Feb 1. PMID: 26898973 </br>3:Inhibition of ATP synthesis by fenbufen and its conjugated metabolites in rat liver mitochondria. Syed M, Skonberg C, Hansen SH.Toxicol In Vitro. 2016 Mar;31:23-9. doi: 10.1016/j.tiv.2015.11.013. Epub 2015 Nov 21. PMID: 26612354 </br>4:Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies. Dhaneshwar S, Kusurkar M, Bodhankar S, Bihani G.Inflammopharmacology. 2014 Aug;22(4):235-50. doi: 10.1007/s10787-013-0194-4. Epub 2013 Nov 1. PMID: 24178955 </br>5:[123I]Iodooctyl fenbufen amide as a SPECT tracer for imaging tumors that over-express COX enzymes. Huang HL, Yeh CN, Lee WY, Huang YC, Chang KW, Lin KJ, Tien SF, Su WC, Yang CH, Chen JT, Lin WJ, Fan SS, Yu CS.Biomaterials. 2013 Apr;34(13):3355-65. doi: 10.1016/j.biomaterials.2013.01.050. Epub 2013 Feb 4. PMID: 23384791 Free Article</br>6:Density functional theory study on the molecular structure and vibration spectra of fenbufen. Yang Y, Gao H.Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jan 15;101:119-26. doi: 10.1016/j.saa.2012.09.034. Epub 2012 Sep 26. PMID: 23099169 </br>7:Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries. Su YH, Chiang LW, Jeng KC, Huang HL, Chen JT, Lin WJ, Huang CW, Yu CS.Bioorg Med Chem Lett. 2011 Mar 1;21(5):1320-4. doi: 10.1016/j.bmcl.2011.01.068. Epub 2011 Jan 22. PMID: 21315586 </br>8:Synthesis and structure-activity relationships of fenbufen amide analogs. Lin KI, Yang CH, Huang CW, Jian JY, Huang YC, Yu CS.Molecules. 2010 Dec 2;15(12):8796-803. doi: 10.3390/molecules15128796. PMID: 21127465 Free Article</br>9:Inclusion and release of fenbufen in mesoporous silica. Carriazo D, del Arco M, Fernández A, Martín C, Rives V.J Pharm Sci. 2010 Aug;99(8):3372-80. doi: 10.1002/jps.22096. PMID: 20232455 </br>10:Single dose oral fenbufen for acute postoperative pain in adults. Moore RA, Derry S, McQuay HJ.Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007547. doi: 10.1002/14651858.CD007547.pub2. Review. PMID: 19821427 Free PMC Article

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