Felbamate - CAS 25451-15-4
Felbamate is an anti-epileptic drug used in the treatment of epilepsy. Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptors, the relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.
Catalog Number: A000408
CAS Number: 25451-15-4
PubChem Substance ID:355038877
Molecular Formula: C11H14N2O4
Molecular Weight:238.2
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | 25451-15-4; Felbatol; 2-Phenylpropane-1,3-diyl dicarbamate; 2-Phenyl-1,3-propanediol dicarbamate; Felbamyl |
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Property
Molecular Formula: | C11H14N2O4 |
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Molecular Weight | 238.2 |
Target: | NMDA Receptor |
Solubility | Soluble in DMSO > 10 mM |
Purity | ≥95% |
Storage | -20°C |
Computed Descriptor
InChI | 1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15) |
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InChIKey | WKGXYQFOCVYPAC-UHFFFAOYSA-N |
SMILES | C1=CC=C(C=C1)C(COC(=O)N)COC(=O)N |