Difluprednate

• CAT Number: A000854
• CAS Number: 23674-86-4
• Molecular Formula: C27H34F2O7
• Molecular Weight: 508.55
• Purity: ≥95%
• Storage: RT
• InChI: InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1
• InChIKey: WYQPLTPSGFELIB-JTQPXKBDSA-N
• SMILES: CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C

Difluprednate is a corticosteroid, It is chemically a butyrate ester of 6(alpha),9(alpha)-difluoro prednisolone acetate. Accordingly, difluprednate is sometimes abbreviated DFBA, for difluoroprednisolone butyrate acetate.

Reference

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2: Abessi B, Brooksby L, Schultze RL. Comparison of Efficacy of Difluprednate
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3: Tijunelis MA, Person E, Niziol LM, Musch DC, Ernest P, McBain M, Mian SI.
Comparison of prednisolone acetate 1.0% and difluprednate ophthalmic emulsion
0.05% after cataract surgery: Incidence of postoperative steroid-induced ocular
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5: Garg P, Tuteja N, Qayum S. To Study the Efficacy of Difluprednate Ophthalmic
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6: Kusne Y, Kang P, Fintelmann RE. A retrospective analysis of intraocular
pressure changes after cataract surgery with the use of prednisolone acetate 1%
versus difluprednate 0.05%. Clin Ophthalmol. 2016 Nov 23;10:2329-2336.
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7: Kaur S, Sukhija J. Difluprednate versus prednisolone acetate for inflammation
following cataract surgery in pediatric patients: a randomized safety and
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8: Wilson ME, Lambert SR, Plager DA, VanderVeen D, Roarty J, O/’Halloran H.
Difluprednate versus prednisolone acetate for inflammation following cataract
surgery in pediatric patients: a randomized safety and efficacy study. Eye
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9: Lu S, Taban M. Topical difluprednate for treatment of serous retinal
detachment and panuveitis associated with Vogt-Koyanagi-Harada disease. Digit J
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10: Feiler DL, Srivastava SK, Pichi F, Bena J, Lowder CY. RESOLUTION OF
NONINFECTIOUS UVEITIC CYSTOID MACULAR EDEMA WITH TOPICAL DIFLUPREDNATE. Retina.
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