FAPI-34

• CAT Number: I044410
• CAS Number: 2374782-07-5
• Molecular Formula: C50H57F2N13O18
• Molecular Weight: 1166.06
• Purity: ≥95%
• Synonyms: (3S)-3-[[2-[2-[[[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-[[1-[2-oxo-2-[[(1S)-1,3,3-tricarboxypropyl]amino]ethyl]imidazol-2-yl]methyl]amino]methyl]imidazol-1-yl]acetyl]amino]propane-1,1,3-tricarboxylic acid
• InChI: InChI=1S/C50H57F2N13O18/c51-50(52)19-28(20-53)65(27-50)41(68)21-57-43(70)30-4-5-54-34-3-2-29(16-31(30)34)83-15-1-8-60-11-13-62(14-12-60)42(69)26-61(22-37-55-6-9-63(37)24-39(66)58-35(48(79)80)17-32(44(71)72)45(73)74)23-38-56-7-10-64(38)25-40(67)59-36(49(81)82)18-33(46(75)76)47(77)78/h2-7,9-10,16,28,32-33,35-36H,1,8,11-15,17-19,21-27H2,(H,57,70)(H,58,66)(H,59,67)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)/t28-,35-,36-/m0/s1
• InChIKey: FPOZMWSPTRNDPQ-UVXHQIPUSA-N
• SMILES: C1CN(CCN1CCCOC2=CC3=C(C=CN=C3C=C2)C(=O)NCC(=O)N4CC(C[C@H]4C#N)(F)F)C(=O)CN(CC5=NC=CN5CC(=O)N[C@@H](CC(C(=O)O)C(=O)O)C(=O)O)CC6=NC=CN6CC(=O)N[C@@H](CC(C(=O)O)C(=O)O)C(=O)O

FAPI-34（Cat No.:I044410）is a potent fibroblast activation protein (FAP) inhibitor designed for diagnostic and therapeutic applications, particularly in cancer-associated fibroblast targeting. As a quinoline-based radiotracer precursor, FAPI-34 binds selectively to FAP, which is overexpressed in the tumor stroma of many epithelial cancers but minimally present in normal tissues. This selective affinity enables its use in PET imaging and targeted radionuclide therapy. FAPI-34 supports research into tumor microenvironment modulation, cancer imaging, and stromal-targeted treatment strategies, offering high tumor-to-background contrast and favorable pharmacokinetics for translational and clinical oncology studies.