For research use only. Not for therapeutic Use.
exo-BCN-NHS Carbonate(CAT: I040363) is a highly reactive, amine-targeting bifunctional linker that incorporates a strained alkyne (bicyclo[6.1.0]nonyne, BCN) and an N-hydroxysuccinimide (NHS) carbonate ester. It is widely used in bioorthogonal click chemistry, particularly in strain-promoted alkyne–azide cycloaddition (SPAAC) reactions, allowing for rapid and copper-free conjugation under physiological conditions. The NHS carbonate group enables efficient labeling of primary amines on biomolecules such as proteins, peptides, or antibodies. exo-BCN-NHS Carbonate is ideal for constructing stable bioconjugates, antibody-drug conjugates (ADCs), or functionalized surfaces in biopharmaceutical, diagnostic, and imaging applications, offering high specificity, fast kinetics, and minimal perturbation of biological systems.
| CAS Number | 1493802-77-9 |
| Synonyms | [(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methyl (2,5-dioxopyrrolidin-1-yl) carbonate |
| Molecular Formula | C15H17NO5 |
| Purity | ≥95% |
| IUPAC Name | [(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methyl (2,5-dioxopyrrolidin-1-yl) carbonate |
| InChI | InChI=1S/C15H17NO5/c17-13-7-8-14(18)16(13)21-15(19)20-9-12-10-5-3-1-2-4-6-11(10)12/h10-12H,3-9H2/t10-,11+,12? |
| InChIKey | SKTDJYHCSCYLQU-FOSCPWQOSA-N |
| SMILES | C1CC2C(C2COC(=O)ON3C(=O)CCC3=O)CCC#C1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
