For research use only. Not for therapeutic Use.
Exatecan-methylacetamide-OH(CAT: I040532) is a derivative of Exatecan, a highly potent topoisomerase I inhibitor belonging to the camptothecin class of cytotoxic agents. Featuring a methylacetamide modification and a terminal hydroxyl group, this compound is engineered for enhanced stability and functionalization, making it particularly suitable as a payload in the design of antibody-drug conjugates (ADCs). Exatecan-methylacetamide-OH retains strong DNA-damaging activity, leading to replication arrest and apoptosis in proliferating cancer cells. It is ideal for oncology research, especially in studies involving targeted drug delivery, linker optimization, and payload efficacy. Supplied in high purity for advanced pharmacological and biochemical investigations.
| CAS Number | 2594423-51-3 |
| Synonyms | N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]-2-hydroxy-N-methylacetamide |
| Molecular Formula | C27H26FN3O6 |
| Purity | ≥95% |
| IUPAC Name | N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]-2-hydroxy-N-methylacetamide |
| InChI | InChI=1S/C27H26FN3O6/c1-4-27(36)16-7-20-24-14(9-31(20)25(34)15(16)11-37-26(27)35)23-19(30(3)21(33)10-32)6-5-13-12(2)17(28)8-18(29-24)22(13)23/h7-8,19,32,36H,4-6,9-11H2,1-3H3/t19-,27-/m0/s1 |
| InChIKey | CPTRGGHYNGTFRJ-PPHZAIPVSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N(C)C(=O)CO)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
