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EVP-6124 hydrochloride

EVP-6124 hydrochloride

  • CAT Number: I004044
  • CAS Number: 550999-74-1
  • Molecular Formula: C16H18Cl2N2OS
  • Molecular Weight: 357.3
  • Purity: ≥95%
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EVP-6124 hydrochloride (Cat.No:I004044) is a selective α7 nicotinic acetylcholine receptor agonist. It shows potential in the treatment of cognitive impairments associated with various neuropsychiatric disorders, including Alzheimer’s disease and schizophrenia. EVP-6124 hydrochloride modulates neurotransmitter release and enhances cognitive function. Ongoing research aims to explore its therapeutic applications further.

Catalog Number I004044
CAS Number 550999-74-1
Molecular Formula

C16H18Cl2N2OS

Purity 95%
Target Nicotinic Receptor
Solubility DMSO 100 mg/ml
Storage Store at -20°C
IUPAC Name N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide;hydrochloride
InChI InChI=1S/C16H17ClN2OS.ClH/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19;/h1-3,8,10,13H,4-7,9H2,(H,18,20);1H/t13-;/m0./s1
InChIKey OIJYTJGIDVTCFF-ZOWNYOTGSA-N
SMILES C1CN2CCC1[C@H](C2)NC(=O)C3=CC4=C(S3)C(=CC=C4)Cl.Cl
Reference

<p style=/line-height:25px/>
<br>[1]. Prickaerts J, van Goethem NP, Chesworth R et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62(2):1099-110.
<br>[2]. In development for Alzheimer disease and schizophrenia
</p>

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