ETP-45658

• CAT Number: I011008
• CAS Number: 1198357-79-7
• Molecular Formula: C16H17N5O2
• Molecular Weight: 311.34
• Purity: ≥95%
• Synonyms: 3-(1-methyl-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-6-yl)phenol
• InChI: InChI=1S/C16H17N5O2/c1-20-15-13(10-17-20)16(21-5-7-23-8-6-21)19-14(18-15)11-3-2-4-12(22)9-11/h2-4,9-10,22H,5-8H2,1H3
• InChIKey: BJVRNXSHJLDZJR-UHFFFAOYSA-N
• SMILES: CN1C2=C(C=N1)C(=NC(=N2)C3=CC(=CC=C3)O)N4CCOCC4

ETP-45658 (Cat No.: I011008) is a selective small-molecule inhibitor of the fibroblast growth factor receptor 1 (FGFR1) tyrosine kinase. By blocking FGFR1 activity, it disrupts signaling pathways involved in cell proliferation, angiogenesis, and survival, making it a valuable tool in cancer research. ETP-45658 is applied in preclinical studies to investigate FGFR-driven tumorigenesis, resistance mechanisms, and potential therapeutic strategies. Its specificity provides insights into FGFR1-mediated biology without extensive off-target effects. While not developed for clinical use, it remains an important probe in oncology drug discovery.

Reference

[1]. Link W, et, al. Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J Biol Chem. 2009 Oct 9;284(41):28392-28400.
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[2]. Hill R, et, al. A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 2014 De
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