Etoricoxib

• CAT Number: I002556
• CAS Number: 202409-33-4
• Molecular Formula: C₁₈H₁₅ClN₂O₂S
• Molecular Weight: 358.84
• Purity: ≥95%
• Target: COX
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IC50: 1.1 uM (LPS-induced prostaglandin E2 synthesis)
• IUPAC Name: 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
• InChI: InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
• InChIKey: MNJVRJDLRVPLFE-UHFFFAOYSA-N
• SMILES: CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C

Etoricoxib (Cat No.: I002556) is a non-steroidal anti-inflammatory drug, which has anti-inflammatory, analgesic and antipyretic effects in animal models. Etoricoxib is a selective inhibitor of cyclooxygenase-2, which can alleviate these symptoms and signs, reduce gastrointestinal side effects and not affect platelet function.

Reference

1:[Evidence of feasibility etoricoxib therapy in osteoarthritis in elderly patients]. Sivordova LE, Zavodovsky BV, Polyakova JV, Akhverdyan YR.Adv Gerontol. 2016;29(2):286-290. Russian. PMID: 28514547 2:Protective multimodal analgesia with etoricoxib and spinal anesthesia in inguinal hernia repair: a randomized controlled trial. Somri M, Hawash N, Hadjittofi C, Ghantous-Toukan M, Tome R, Yodashkin M, Matter I.J Anesth. 2017 Apr 28. doi: 10.1007/s00540-017-2368-5. [Epub ahead of print] PMID: 28455600 3:Clinical, Biochemical and Genetic Features of 41 Han Chinese Families with Primary Hypertrophic Osteoarthropathy, and Their Therapeutic Response to Etoricoxib: Results from a 6 Months Prospective Clinical Intervention. Li SS, He JW, Fu WZ, Liu YJ, Hu YQ, Zhang ZL.J Bone Miner Res. 2017 Apr 20. doi: 10.1002/jbmr.3157. [Epub ahead of print] PMID: 28425581 4:Seizure following the Use of the COX-2 Inhibitor Etoricoxib. Arnao V, Riolo M, Fierro B, Aridon P.Case Rep Neurol Med. 2017;2017:1410759. doi: 10.1155/2017/1410759. Epub 2017 Jan 22. PMID: 28210513 Free PMC Article5:Pharmacokinetics and Cardiovascular Effect of Etoricoxib in the Absence or Presence of St. John/’s Wort in Rats. [No authors listed]Drug Res (Stuttg). 2017 Feb;67(2):131. doi: 10.1055/s-0042-123005. Epub 2017 Feb 7. No abstract available. PMID: 28173604 6:[The efficacy and safety of etoricoxib versus meloxicam in the treatment of patients with gonarthrosis]. Zavodovsky BV, Sivordova LE, Polyakova YV, Akhverdyan YR, Kuznetsova MI, Zborovskaya IA.Ter Arkh. 2016;88(12):78-81. Russian. PMID: 28139564 7:Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile. Alsayed SS, Elshemy HA, Abdelgawad MA, Abdel-Latif MS, Abdellatif KR.Bioorg Chem. 2017 Feb;70:173-183. doi: 10.1016/j.bioorg.2016.12.008. Epub 2016 Dec 26. PMID: 28057325 8:Trends in celecoxib and etoricoxib prescribing following removal of prior authorization requirement in Spain. Carracedo-Martínez E, Pia-Morandeira A, Figueiras A.J Clin Pharm Ther. 2017 Apr;42(2):185-188. doi: 10.1111/jcpt.12490. Epub 2016 Dec 15. PMID: 27982453 9:Fixed drug eruption by etoricoxib confirmed by patch test. Sousa AS, Cardoso JC, Gouveia MP, Gameiro AR, Teixeira VB, Gonçalo M.An Bras Dermatol. 2016 Sep-Oct;91(5):652-654. doi: 10.1590/abd1806-4841.20164301. PMID: 27828643 Free PMC Article10:Mucosal exfoliation as a selective reaction to etoricoxib. Patanè M, Isola S, Gangemi S, Minciullo PL.J Clin Pharm Ther. 2016 Dec;41(6):722-724. doi: 10.1111/jcpt.12445. Epub 2016 Aug 31. PMID: 27576781