Ethosuximide

  • CAT Number: A000069
  • CAS Number: 77-67-8
  • Molecular Formula: C7H11NO2
  • Molecular Weight: 141.17
  • Purity: ≥95%
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Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures. Ethosuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli.

Catalog Number A000069
CAS Number 77-67-8
Molecular Formula

C7H11NO2

Purity 95%
Storage Store at -20°C
InChI 1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChIKey HAPOVYFOVVWLRS-UHFFFAOYSA-N
SMILES CCC1(CC(=O)NC1=O)C
Reference

1: San-José P, Cano-Corres R, Aguadero V, Miralles-Albors P, Berlanga-Escalera E.
Interference between ethosuximide and barbiturates in an immunochromatographic
method. Clin Chem Lab Med. 2017 Aug 1. pii:
/j/cclm.ahead-of-print/cclm-2017-0441/cclm-2017-0441.xml. doi:
10.1515/cclm-2017-0441. [Epub ahead of print] PubMed PMID: 28763298.
<br>

2: Kerckhove N, Scanzi J, Pereira B, Ardid D, Dapoigny M. Assessment of the
effectiveness and safety of ethosuximide in the treatment of abdominal pain
related to irritable bowel syndrome – IBSET: protocol of a randomised, parallel,
controlled, double-blind and multicentre trial. BMJ Open. 2017 Jul
18;7(7):e015380. doi: 10.1136/bmjopen-2016-015380. PubMed PMID: 28720615.
<br>

3: Sang L, Zheng T, Min L, Zhang X, Ma X, Entenman S, Su Y, Zheng Q.
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing
loss. Int J Mol Med. 2017 Jul;40(1):146-154. doi: 10.3892/ijmm.2017.3004. Epub
2017 May 26. PubMed PMID: 28560432; PubMed Central PMCID: PMC5466398.
<br>

4: Ji Y, Lin J, Peng X, Liu X, Li F, Zhang Y, Guo N, Li Q. Behavioural responses
of zebrafish larvae to acute ethosuximide exposure. Behav Pharmacol. 2017
Sep;28(6):428-440. doi: 10.1097/FBP.0000000000000312. PubMed PMID: 28537944.

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5: Brigo F, Igwe SC. Ethosuximide, sodium valproate or lamotrigine for absence
seizures in children and adolescents. Cochrane Database Syst Rev. 2017 Feb
14;2:CD003032. doi: 10.1002/14651858.CD003032.pub3. Review. PubMed PMID:
28195639.
<br>

6: Toyama T, Asano Y, Taniguchi T, Takahashi T, Ichimura Y, Tamaki Z, Kagami S,
Mitsui H, Sato S. Ethosuximide-induced lupus-scleroderma syndrome with
disease-specific autoantibodies. Eur J Dermatol. 2017 Apr 1;27(2):196-197. doi:
10.1684/ejd.2016.2942. PubMed PMID: 28026802.
<br>

7: Kerckhove N, Mallet C, Pereira B, Chenaf C, Duale C, Dubray C, Eschalier A.
Assessment of the effectiveness and safety of Ethosuximide in the Treatment of
non-Diabetic Peripheral Neuropathic Pain: EDONOT-protocol of a randomised,
parallel, controlled, double-blinded and multicentre clinical trial. BMJ Open.
2016 Dec 16;6(12):e013530. doi: 10.1136/bmjopen-2016-013530. PubMed PMID:
27986742; PubMed Central PMCID: PMC5168699.
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8: Gironell A, Marin-Lahoz J. Ethosuximide for Essential Tremor: An Open-Label
Trial. Tremor Other Hyperkinet Mov (N Y). 2016 Jul 13;6:378. doi:
10.7916/D8FQ9WN0. eCollection 2016. PubMed PMID: 27625899; PubMed Central PMCID:
PMC4947198.
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9: IJff DM, van Veenendaal TM, Debeij-van Hall MH, Jansen JF, de Louw AJ, Majoie
MH, Aldenkamp AP. The Cognitive Profile of Ethosuximide in Children. Paediatr
Drugs. 2016 Oct;18(5):379-85. doi: 10.1007/s40272-016-0187-z. PubMed PMID:
27557905.
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10: Ghamkhari Nejad G, Shahabi P, Alipoor MR, Ghaderi Pakdel F, Asghari M,
Sadighi Alvandi M. Ethosuximide Affects Paired-Pulse Facilitation in
Somatosensory Cortex of WAGRij Rats as a Model of Absence Seizure. Adv Pharm
Bull. 2015 Nov;5(4):483-9. doi: 10.15171/apb.2015.066. Epub 2015 Nov 30. PubMed
PMID: 26819920; PubMed Central PMCID: PMC4729345.

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