Estriol

• CAT Number: A000212
• CAS Number: 50-27-1
• Molecular Formula: C18H24O3
• Molecular Weight: 288.4
• Purity: ≥95%
• Target: Estrogen/progestogen Receptor
• Solubility: >9.3mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
• InChIKey: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• SMILES: CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O

Estriol (CAT: A000212) is a naturally occurring hormone belonging to the class of compounds known as estrogens. Estrogens are predominantly produced by the ovaries during the menstrual cycle and play a crucial role in the development and maintenance of female sexual characteristics and reproductive health.

Reference

1: Wang C, Guan D, Chen C, He S, Liu X, Wang C, Wu H. Rapid detection of
unconjugated estriol in the serum via superparamagnetic lateral flow
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2: Mendes-Bastos P. Plantar keratoderma climatericum: Successful improvement with
a topical estriol cream. J Cosmet Dermatol. 2017 Sep 19. doi: 10.1111/jocd.12422.
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3: Otsuka M, Kadokawa H. GPR30 mediates estrone, estriol, and estradiol to
suppress gonadotropin-releasing hormone-induced luteinizing hormone secretion in
the anterior pituitary of heifers. J Reprod Dev. 2017 Oct 18;63(5):519-525. doi:
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4: Cruz VL, Steiner ML, Pompei LM, Strufaldi R, Fonseca FLA, Santiago LHS,
Wajsfeld T, Fernandes CE. Randomized, double-blind, placebo-controlled clinical
trial for evaluating the efficacy of fractional CO2 laser compared with topical
estriol in the treatment of vaginal atrophy in postmenopausal women. Menopause.
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5: Raymundo-Pereira PA, Campos AM, Vicentini FC, Janegitz BC, Mendonça CD, Furini
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6: Liu J, Li S, Li X, Gao Y, Ling W. Removal of estrone, 17β-estradiol, and
estriol from sewage and cow dung by immobilized Novosphingobium sp. ARI-1.
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7: Ramírez-Sánchez IM, Tuberty S, Hambourger M, Bandala ER. Resource efficiency
analysis for photocatalytic degradation and mineralization of estriol using
TiO(2) nanoparticles. Chemosphere. 2017 Oct;184:1270-1285. doi:
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8: Rueda C, Osorio AM, Avellaneda AC, Pinzón CE, Restrepo OI. The efficacy and
safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a
systematic literature review. Climacteric. 2017 Aug;20(4):321-330. doi:
10.1080/13697137.2017.1329291. Epub 2017 Jun 16. PubMed PMID: 28622049.

9: Ali ES, Mangold C, Peiris AN. Estriol: emerging clinical benefits. Menopause.
2017 Sep;24(9):1081-1085. doi: 10.1097/GME.0000000000000855. PubMed PMID:
28375935.

10: Caruso S, Cianci S, Vitale SG, Matarazzo MG, Amore FF, Cianci A. Effects of
ultralow topical estriol dose on vaginal health and quality of life in
postmenopausal women who underwent surgical treatment for pelvic organ prolapse.
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PMID: 28350758.