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Estramustine phosphate sodium

Estramustine phosphate sodium

  • CAT Number: I003898
  • CAS Number: 52205-73-9
  • Molecular Formula: C23H30Cl2NNa2O6P
  • Molecular Weight: 564.35
  • Purity: ≥95%
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Estramustine phosphate sodium (Cat No.: I003898) is an antineoplastic drug with a unique dual mode of action. The metabolites estrone and estradiol of Estramustine phosphate sodium have anti-gonadotropic activity, resulting in a decrease in testosterone levels. Estramustine phosphate sodium dephosphorylated cytotoxic metabolite) is an anti-prostate tumor drug with anti-microtubule effects.

Catalog Number I003898
CAS Number 52205-73-9
Molecular Formula

C23H30Cl2NNa2O6P

Purity 95%
Solubility 10 mM in H2O, DMSO: ＜ 7.8 mg/mL
Storage Inert atmosphere,2-8°C
IUPAC Name disodium;[(8R,9S,13S,14S,17S)-3-[bis(2-chloroethyl)carbamoyloxy]-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] phosphate
InChI InChI=1S/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/q;2*+1/p-2/t18-,19-,20+,21+,23+;;/m1../s1
InChIKey IIUMCNJTGSMNRO-VVSKJQCTSA-L
SMILES CC12CCC3C(C1CCC2OP(=O)([O-])[O-])CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl.[Na+].[Na+]
Reference

<p style=/line-height:25px/>
<br>[1]. Perry CM, et al. Estramustine phosphate sodium. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1995 Jul;7(1):49-74.
<br>[2]. Bergenheim AT, et al. Pharmacokinetics and pharmacodynamics of estramustine phosphate. Clin Pharmacokinet. 1998 Feb;34(2):163-72.
<br>[3]. Dene Simpson, et al. Estramustine Phosphate Sodium. American Journal of Cancer 2 (5): 373–390.
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