EST64454 hydrochloride

• CAT Number: I027022
• CAS Number: 1950569-11-5
• Molecular Formula: C18H23ClF2N4O2
• Molecular Weight: 400.85
• Purity: ≥95%
• Synonyms: 1-[4-[2-[[1-(3,4-difluorophenyl)pyrazol-3-yl]methoxy]ethyl]piperazin-1-yl]ethanone;hydrochloride
• InChI: InChI=1S/C18H22F2N4O2.ClH/c1-14(25)23-8-6-22(7-9-23)10-11-26-13-15-4-5-24(21-15)16-2-3-17(19)18(20)12-16;/h2-5,12H,6-11,13H2,1H3;1H
• InChIKey: YJZGDOPAALDWAT-UHFFFAOYSA-N
• SMILES: CC(=O)N1CCN(CC1)CCOCC2=NN(C=C2)C3=CC(=C(C=C3)F)F.Cl

EST64454 hydrochloride (Cat No.: I027022) is a small-molecule inhibitor of tropomyosin receptor kinase B (TrkB), a receptor for brain-derived neurotrophic factor (BDNF) involved in neuronal survival, differentiation, and synaptic plasticity. By blocking TrkB signaling, EST64454 hydrochloride modulates downstream pathways such as PI3K/Akt and MAPK/ERK, affecting neurotrophic support and cell growth. It is used in neuroscience research to study TrkB-mediated processes in neurodegenerative diseases, mood disorders, and cancer, providing a tool for evaluating the therapeutic potential of TrkB inhibition in various pathological contexts.

Reference

[1]. Díaz JL, et al. EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem. 2020;63(23):14979-14988.
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