ERK-IN-4

• CAT Number: R065139
• CAS Number: 1049738-54-6
• Molecular Formula: C14H17ClN2O3S
• Molecular Weight: 328.81
• Purity: ≥95%
• Synonyms: (5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione;hydrochloride
• InChI: InChI=1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H/b12-9-
• InChIKey: PQVLWVGMXJPJLG-MWMYENNMSA-N
• SMILES: CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl

ERK-IN-4 (Cat No.: R065139) is a selective small-molecule inhibitor targeting extracellular signal-regulated kinases 1 and 2 (ERK1/2), key components of the MAPK/ERK signaling pathway involved in cell proliferation, differentiation, and survival. By blocking ERK activity, ERK-IN-4 disrupts downstream signaling in oncogenic RAS/RAF-driven cancers, where ERK acts as a critical effector. This inhibitor is valuable in cancer research for investigating resistance mechanisms to upstream MEK or RAF inhibitors and for developing combination therapies. ERK-IN-4 supports the exploration of targeted strategies in precision oncology.

Reference

[1]. Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95.
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