Ergoloid Mesylates

  • CAT Number: I004938
  • CAS Number: 8067-24-1
  • Molecular Formula: C20H29N3O5S
  • Molecular Weight: 423.53
  • Purity: ≥95%
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Ergoloid mesylates (CAT: I004938) are a mixture of alkaloid derivatives derived from ergot fungi. These compounds have pharmacological actions that are not fully understood, but they are believed to have a modulatory effect on various neurotransmitter systems in the brain, including dopamine, serotonin, and norepinephrine. Ergoloid mesylates have been used in the treatment of age-related cognitive decline, dementia, and related conditions. They are thought to enhance cognitive function, improve memory, and increase cerebral blood flow. The precise mechanisms of action are complex and multifaceted, involving interactions with multiple receptors and neurotransmitter systems. Further research is needed to fully elucidate the therapeutic potential of ergoloid mesylates in various neurological conditions.

Catalog Number I004938
CAS Number 8067-24-1
Synonyms

(6aR,9R,10aR,Z)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carbimidic acid compound with methanesulfonic acid (1:1); Dihydroergotoxine monomethanesulfonate (salt); An equiproportional mixture of dihydroergocornine of mesylate, dihydroergocristine mesylate, and ratio of dihydro-a-ergocryptine mesylate to dihydro-b-ergocryptine mesylate is (1.5-2.5:1)

Molecular Formula

C20H29N3O5S

Purity 95%
Target GABA Receptor
Solubility DMSO: ≥ 31 mg/mL
Storage Store at RT
Reference

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1. Tvrdeic A, et al. Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore. Eur J Pharmacol. 1991 Sep 4;202(1):109-11.<br />
2. Tvrdeic A, et al. Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain. Eur J Pharmacol. 1992 Oct 6;221(1):139-43.<br />
3. Tvrdeic A, et al. Effect of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors. Coll Antropol. 2003;27 Suppl 1:175-82.<br />
4. Abdul M, et al. Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer. Acta Oncol. 2008;47(8):1546-50.</p>

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