EPZ004777 - CAS 1338466-77-5

EPZ004777 (CAT: I001291) is a highly potent and selective inhibitor of DOT1L, with an IC50 of 0.4 nM. By targeting the catalytic activity of DOT1L, EPZ004777 effectively inhibits H3K79 methylation, leading to the suppression of leukemogenic gene expression in mixed lineage leukemia (MLL). This specific targeting enables the selective killing of MLL-translocated cells while sparing non-MLL-translocated cells. In preclinical studies, EPZ004777 has shown promising results, extending the survival of MLL xenograft mice. These findings support the potential of DOT1L inhibition, such as with EPZ004777, as a targeted therapeutic strategy for MLL and highlight its potential for further development in leukemia treatment.

Catalog Number: I001291

CAS Number: 1338466-77-5

PubChem Substance ID:355039360

Molecular Formula: C₂₈H₄₁N₇O₄

Molecular Weight:539.67

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea

Property

Molecular Formula: C₂₈H₄₁N₇O₄
Molecular Weight539.67
Target:Histone Methyltransferase
SolubilityDMSO 100 mg/ml
Purity≥95%
Storage-20°C
IC500.4 nM

Computed Descriptor

InChIInChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26?/m1/s1
InChIKeyWXRGFPHDRFQODR-QQNJPBSNSA-N
SMILESCC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O