EPZ004777 hydrochloride（Cat No.:I001466） is a selective inhibitor of lysine-specific demethylase 1 (LSD1), an enzyme involved in the regulation of gene expression through histone modifications. It acts by binding to the catalytic domain of LSD1, inhibiting its demethylase activity. EPZ004777 hydrochloride has demonstrated potent antiproliferative activity against cancer cells, particularly in leukemia and neuroblastoma models. It is being investigated as a potential therapeutic agent for the treatment of various cancers and other diseases associated with dysregulated histone methylation.
| Catalog Number | I001466 |
| CAS Number | 1380316-03-9 |
| Synonyms | 1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea;hydrochloride |
| Molecular Formula | C28H41N7O4.HCl |
| Purity | 95% |
| Target | Histone Methyltransferase |
| Solubility | 10 mM in DMSO |
| Storage | 4°C, protect from light |
| IC50 | 0.4 nM [1] |
| IUPAC Name | 1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea;hydrochloride |
| InChI | InChI=1S/C28H41N7O4.ClH/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35;/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38);1H/t21-,22-,23-,26-;/m1./s1 |
| InChIKey | NPEPLDAFAVXSBD-XRJUUMFPSA-N |
| SMILES | CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C(N=CN=C43)N)O)O.Cl |
| Reference | <p style=/line-height:25px/> <br>[2]. Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22. <br>[3]. Deshpande AJ, et al. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.Blood. 2013 Mar 28;121(13):2533-41. </p> |
