Eptifibatide acetate

• CAT Number: I006694
• CAS Number: 188627-80-7 (free base).
• Molecular Formula: C37H53N11O11S2
• Molecular Weight: 892.017
• Purity: ≥95%
• Target: Platelet Aggregation Inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• InChI: InChI=1S/C35H49N11O9S2.C2H4O2/c36-30(51)25-18-57-56-13-10-27(47)42-22(8-3-4-11-39-35(37)38)31(52)41-17-28(48)43-23(15-29(49)50)32(53)44-24(14-19-16-40-21-7-2-1-6-20(19)21)34(55)46-12-5-9-26(46)33(54)45-25;1-2(3)4/h1-2,6-7,16,22-26,40H,3-5,8-15,17-18H2,(H2
• InChIKey: KWKBRYJYRIUYEI-QMYFOHRPSA-N
• SMILES: NC(NCCCC[C@@H]1NC(CCSSC[C@@H](C(N)=O)NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC(CNC1=O)=O)CC(O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=N.CC(O)=O

Eptifibatide, also co-promoted by Schering-Plough/Essex, is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.

Reference

1:Pothineni NV, Watts TE, Ding Z, Dai Y, Deshmukh AJ. Eptifibatide-Induced Thrombocytopenia-When Inhibitor Turns Killer. Am J Ther. 2016 Jan-Feb;23(1):e298-9. doi: 10.1097/01.mjt.0000438283.01797.1a. PubMed PMID: 24368608.