Epinephrine

  • CAT Number: A000753
  • CAS Number: 51-43-4
  • Molecular Formula: C9H13NO3
  • Molecular Weight: 183.2
  • Purity: ≥95%
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Adrenaline (Cat No.:A000753), also known as L-Adrenaline, is a hormone secreted by chromophores in the adrenal medulla. It is mainly involved in the regulation of sympathetic nervous system. It is a non-steroidal hormone drug, also used as an intermediate of the hemostatic drug Aniloxin.

Catalog Number A000753
CAS Number 51-43-4
Synonyms

L-Adrenaline; Adrenaline; L-epinephrine; Adrenalin; Levoepinephrine

Molecular Formula

C9H13NO3

Purity 95%
Target Adrenergic Receptor
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
InChIKey UCTWMZQNUQWSLP-VIFPVBQESA-N
SMILES CNCC(C1=CC(=C(C=C1)O)O)O
Reference

1: Bartos JA, Voicu S, Matsuura TR, Tsangaris A, Sideris G, Oestreich BA, George
SA, Olson M, Shekar KC, Rees JN, Carlson K, Sebastian P, McKnite S, Raveendran G,
Aufderheide TP, Yannopoulos D. Role of epinephrine and extracorporeal membrane
oxygenation in the management of ischemic refractory ventricular fibrillation: a
randomized trial in pigs. JACC Basic Transl Sci. 2017 Jun;2(3):244-253. doi:
10.1016/j.jacbts.2017.02.003. Epub 2017 Jun 21. PubMed PMID: 29152600; PubMed
Central PMCID: PMC5693223.
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2: Abrams EM, Singer AG, Lix L, Katz A, Yogendran M, Simons FER. Adherence with
epinephrine autoinjector prescriptions in primary care. Allergy Asthma Clin
Immunol. 2017 Nov 10;13:46. doi: 10.1186/s13223-017-0218-5. eCollection 2017.
PubMed PMID: 29151840; PubMed Central PMCID: PMC5680749.
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3: Al-Noori S, Cimpan A, Maltzer Z, Kaiyala KJ, Ramsay DS. Plasma corticosterone,
epinephrine, and norepinephrine levels increase during administration of nitrous
oxide in rats. Stress. 2017 Nov 16:1-5. doi: 10.1080/10253890.2017.1402175. [Epub
ahead of print] PubMed PMID: 29145764.

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4: Feuille E, Lawrence C, Volel C, Sicherer SH, Wang J. Time Trends in Food
Allergy Diagnoses, Epinephrine Orders, and Epinephrine Administrations in New
York City Schools. J Pediatr. 2017 Nov;190:93-99. doi:
10.1016/j.jpeds.2017.07.038. PubMed PMID: 29144278.
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5: Dong W, Ren Y, Bai Z, Jiao J, Chen Y, Han B, Chen Q. Synthesis of
tetrahexahedral Au-Pd core-shell nanocrystals and reduction of graphene oxide for
the electrochemical detection of epinephrine. J Colloid Interface Sci. 2017 Oct
31;512:812-818. doi: 10.1016/j.jcis.2017.10.071. [Epub ahead of print] PubMed
PMID: 29121608.
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6: Liu JL, Zeng WN, Wang FY, Chen C, Gong XY, Yang H, Tan ZJ, Jia XL, Yang L.
Effects of low-dose epinephrine on perioperative hemostasis and inflammatory
reaction in major surgeries: a randomized clinical trial. J Thromb Haemost. 2017
Nov 6. doi: 10.1111/jth.13896. [Epub ahead of print] PubMed PMID: 29108091.
<br>

7: Grippi C, Izzi B, Gianfagna F, Noro F, Falcinelli E, Di Pardo A, Amico E,
Donati MB, de Gaetano G, Iacoviello L, Hoylaerts MF, Cerletti C. Neuromedin U
potentiates ADP- and epinephrine-induced human platelet activation. Thromb Res.
2017 Sep 29;159:100-108. doi: 10.1016/j.thromres.2017.09.027. [Epub ahead of
print] PubMed PMID: 29078099.
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8: Katz D, Hamburger J, Gutman D, Wang R, Lin HM, Marotta M, Zahn J, Beilin Y.
The Effect of Adding Subarachnoid Epinephrine to Hyperbaric Bupivacaine and
Morphine for Repeat Cesarean Delivery: A Double-Blind Prospective Randomized
Control Trial. Anesth Analg. 2017 Oct 26. doi: 10.1213/ANE.0000000000002542.
[Epub ahead of print] PubMed PMID: 29077615.

<br>
9: Fukuda T, Kondo Y, Hayashida K, Sekiguchi H, Kukita I. Time to epinephrine and
survival after paediatric out-of-hospital cardiac arrest. Eur Heart J Cardiovasc
Pharmacother. 2017 Jul 11. doi: 10.1093/ehjcvp/pvx023. [Epub ahead of print]
PubMed PMID: 29036580.
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10: Smith N, Giordano K, Thompson A, DePiero A. Failure of Outpatient Management
With Different Observation Times After Racemic Epinephrine for Croup. Clin
Pediatr (Phila). 2017 Oct 1:9922817737075. doi: 10.1177/0009922817737075. [Epub
ahead of print] PubMed PMID: 29034735.

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