(-)-Epicatechin gallate

• CAT Number: I001029
• CAS Number: 1257-08-5
• Molecular Formula: C22H18O10
• Molecular Weight: 442.4
• Purity: ≥95%
• Target: PKC
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• InChIKey: LSHVYAFMTMFKBA-TZIWHRDSSA-N

(-)-Epicatechin gallate is a flavan-3-ol, a type of flavonoid, present in green tea.IC50 value:Target:in vitro: epicatechin gallate, a constituent of an extract of tea leaves (green tea) markedly lowered the minimum inhibitory concentration (MIC) of oxacillin and other beta-lactams, but not of other antibacterial agents tested, in strains of methicillin-resistant Staphylococcus aureus [1]. Epicatechin, as well as many other flavonoids, has been found to act as a non-selective antagonist of the opioid receptors, albeit with somewhat low affinity [2].

Reference

1:Effect of ultrasound on the interaction between (-)-epicatechin gallate and bovine serum albumin in a model wine. Zhang QA, Fu XZ, García Martín JF.Ultrason Sonochem. 2017 Jul;37:405-413. doi: 10.1016/j.ultsonch.2017.01.031. Epub 2017 Jan 30. PMID: 28427650 2:Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression. Mukherjee S, Debata PR, Hussaini R, Chatterjee K, Baidoo JNE, Sampat S, Szerszen A, Navarra JP, Fata J, Severinova E, Banerjee P, Castellanos MR.Oncotarget. 2017 Mar 29. doi: 10.18632/oncotarget.16648. [Epub ahead of print] PMID: 28416754 Free Article3:Extraction of Epigallocatechin Gallate and Epicatechin Gallate from Tea Leaves Using β-Cyclodextrin. Cui L, Liu Y, Liu T, Yuan Y, Yue T, Cai R, Wang Z.J Food Sci. 2017 Feb;82(2):394-400. doi: 10.1111/1750-3841.13622. Epub 2017 Jan 10. PMID: 28071811 4:Effective synthesis of theaflavin-3,3/’-digallate with epigallocatechin-3-O-gallate and epicatechin gallate as substrates by using immobilized pear polyphenol oxidase. Lei S, Xie M, Hu B, Zhou L, Sun Y, Saeeduddin M, Zhang H, Zeng X.Int J Biol Macromol. 2017 Jan;94(Pt A):709-718. doi: 10.1016/j.ijbiomac.2016.10.072. Epub 2016 Oct 22. PMID: 27780760 5:TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma. Piao L, Mukherjee S, Chang Q, Xie X, Li H, Castellanos MR, Banerjee P, Iqbal H, Ivancic R, Wang X, Teknos TN, Pan Q.Oncotarget. 2016 Jul 16. doi: 10.18632/oncotarget.10620. [Epub ahead of print] PMID: 27437871 Free Article6:Autophagic effects of Hibiscus sabdariffa leaf polyphenols and epicatechin gallate (ECG) against oxidized LDL-induced injury of human endothelial cells. Chen JH, Lee MS, Wang CP, Hsu CC, Lin HH.Eur J Nutr. 2016 Jun 18. [Epub ahead of print] PMID: 27318926 7:Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate. Malik S, Suchal K, Bhatia J, Gamad N, Dinda AK, Gupta YK, Arya DS.Lab Invest. 2016 Aug;96(8):853-61. doi: 10.1038/labinvest.2016.60. Epub 2016 May 30. PMID: 27239733 8:Epicatechin gallate, a naturally occurring polyphenol, alters the course of infection with β-lactam-resistant Staphylococcus aureus in the zebrafish embryo. Stevens CS, Rosado H, Harvey RJ, Taylor PW.Front Microbiol. 2015 Sep 28;6:1043. doi: 10.3389/fmicb.2015.01043. eCollection 2015. PMID: 26441953 Free PMC Article9:Impact of the β-Lactam Resistance Modifier (-)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus. Rosado H, Turner RD, Foster SJ, Taylor PW.Int J Mol Sci. 2015 Jul 23;16(8):16710-27. doi: 10.3390/ijms160816710. PMID: 26213914 Free PMC Article10:Assessment of extraction parameters on antioxidant capacity, polyphenol content, epigallocatechin gallate (EGCG), epicatechin gallate (ECG) and iriflophenone 3-C-β-glucoside of agarwood (Aquilaria crassna) young leaves. Tay PY, Tan CP, Abas F, Yim HS, Ho CW.Molecules. 2014 Aug 14;19(8):12304-19. doi: 10.3390/molecules190812304. PMID: 25153858 Free Article