For research use only. Not for therapeutic Use.
Epiblastin A（Cat No.:I011898）is a selective ATPase activity inhibitor of the chromatin remodeling protein TIP5, part of the nucleolar remodeling complex (NoRC). By targeting TIP5, Epiblastin A disrupts chromatin structure and epigenetic regulation, making it a valuable tool for studying transcriptional silencing and rDNA gene regulation. It has shown potent antiproliferative effects in cancer cells, particularly in glioblastoma and other aggressive tumors, by impairing chromatin remodeling and transcriptional repression. Epiblastin A is instrumental in exploring novel cancer epigenetics and holds promise for the development of targeted therapies against chromatin-associated oncogenic pathways.
| CAS Number | 16470-02-3 |
| Synonyms | 6-(3-chlorophenyl)pteridine-2,4,7-triamine |
| Molecular Formula | C12H10ClN7 |
| Purity | ≥95% |
| IUPAC Name | 6-(3-chlorophenyl)pteridine-2,4,7-triamine |
| InChI | InChI=1S/C12H10ClN7/c13-6-3-1-2-5(4-6)7-9(14)18-11-8(17-7)10(15)19-12(16)20-11/h1-4H,(H6,14,15,16,18,19,20) |
| InChIKey | ZWNKKZSRANLVEW-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)C2=NC3=C(N=C(N=C3N=C2N)N)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
