For research use only. Not for therapeutic Use.
EP4 Receptor Antagonist 1(CAT: I016898) is a potent small-molecule inhibitor of the prostaglandin E₂ receptor 4 (EP4), a G protein–coupled receptor implicated in inflammation, cancer progression, pain signaling, and autoimmune disorders. By selectively blocking EP4 signaling, this compound disrupts PGE₂-mediated pathways that regulate immune suppression, angiogenesis, and tumor cell survival. EP4 antagonists are of growing interest as potential therapeutics for cancer immunotherapy, inflammatory diseases, and pain management. EP4 Receptor Antagonist 1 provides a valuable pharmacological tool for dissecting EP4-dependent biological processes and exploring the therapeutic relevance of prostaglandin signaling in preclinical models of oncology and chronic inflammation.
| CAS Number | 2287259-07-6 |
| Synonyms | 4-[(1S)-1-[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid |
| Molecular Formula | C23H21F3N4O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[(1S)-1-[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid |
| InChI | InChI=1S/C23H21F3N4O3/c1-3-4-19-20(21(31)27-14(2)16-7-9-17(10-8-16)22(32)33)30(29-28-19)13-15-5-11-18(12-6-15)23(24,25)26/h3-12,14H,13H2,1-2H3,(H,27,31)(H,32,33)/b4-3+/t14-/m0/s1 |
| InChIKey | ZTWUZRMXAVDXJV-XGACYXMMSA-N |
| SMILES | CC=CC1=C(N(N=N1)CC2=CC=C(C=C2)C(F)(F)F)C(=O)NC(C)C3=CC=C(C=C3)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
