Enoximone

• CAT Number: R036815
• CAS Number: 77671-31-9
• Molecular Formula: C12H12N2O2S
• Molecular Weight: 248.3
• Purity: ≥95%
• Synonyms: 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one; Fenoximone; MDL 17043; Perfan; Perfane; RMI 17043
• Target: PDE
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4C
• IUPAC Name: 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
• InChI: InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)
• InChIKey: ZJKNESGOIKRXQY-UHFFFAOYSA-N
• SMILES: CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)SC

Enoximone is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure.

Reference

1:PDE3 inhibition with enoximone as first-line therapy for severe persistent pulmonary hypertension of the newborn during neonatal transport: a case report. van der Lee R, Peels B, Koopman-Esseboom C.Clin Case Rep. 2016 Nov 23;5(1):18-21. doi: 10.1002/ccr3.748. eCollection 2017 Jan. PMID: 28096983 Free PMC Article2:Oral Enoximone as an Alternative to Protracted Intravenous Medication in Severe Pediatric Myocardial Failure. Furck AK, Bentley S, Bartsota M, Rigby ML, Slavik Z.Pediatr Cardiol. 2016 Oct;37(7):1297-301. doi: 10.1007/s00246-016-1433-4. Epub 2016 Jul 5. PMID: 27377525 3:Use of enoximone in management of anaphylaxis complicated by labetalol use. Hayhoe S, Navapurkar V, Conway Morris A.BMJ Case Rep. 2015 Oct 26;2015. pii: bcr2015212432. doi: 10.1136/bcr-2015-212432. PMID: 26504095 4:Conventional hemodynamic resuscitation may fail to optimize tissue perfusion: an observational study on the effects of dobutamine, enoximone, and norepinephrine in patients with acute myocardial infarction complicated by cardiogenic shock. den Uil CA, Lagrand WK, van der Ent M, Nieman K, Struijs A, Jewbali LS, Constantinescu AA, Spronk PE, Simoons ML.PLoS One. 2014 Aug 1;9(8):e103978. doi: 10.1371/journal.pone.0103978. eCollection 2014. PMID: 25084171 Free PMC Article5:Emergency treatment of status asthmaticus with enoximone. Beute J.Br J Anaesth. 2014 Jun;112(6):1105-8. doi: 10.1093/bja/aeu048. Epub 2014 Mar 17. PMID: 24638233 6:Perioperative administration of enoximone and renal function after cardiac surgery: a propensity-matched analysis. Angeloni E, Melina G, Roscitano A, Refice S, Capuano F, Comito C, Benedetto U, Sinatra R.Int J Cardiol. 2013 Sep 1;167(5):1961-6. doi: 10.1016/j.ijcard.2012.05.021. Epub 2012 May 24. PMID: 22633430 7:Retraction Note: Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. [No authors listed]Intensive Care Med. 2011 Jul;37(7):1229. doi: 10.1007/s00134-011-2216-2. No abstract available. PMID: 21604014 8:The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients: Retraction. [No authors listed]Anesth Analg. 2011 May;112(5):1109. doi: 10.1213/ANE.0b013e31821a937c. Epub 2011 Mar 30. No abstract available. PMID: 21451080 9:Double-blind placebo-controlled comparison of enoximone and dobutamine infusions in patients with moderate to severe chronic heart failure. Bader FM, Gilbert EM, Mehta NA, Bristow MR.Congest Heart Fail. 2010 Nov-Dec;16(6):265-70. doi: 10.1111/j.1751-7133.2010.00185.x. Epub 2010 Oct 19. PMID: 21091611 Free Article10:Assessment of residual viability by enoximone echocardiography in patients with previous myocardial infarction correlation with positron emission tomographic studies and functional follow-up. Lu F, Carlino M, Lu C, Landoni C, Lucignani G, Fragasso G, Di Bello V, Margonato A, Chierchia SL, Marzilli M, Balbarini A.Echocardiography. 2010 May;27(5):544-51. doi: 10.1111/j.1540-8175.2009.01082.x. Epub 2010 Mar 30. PMID: 20374267