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ENMD-2076 Tartrate

ENMD-2076 Tartrate

  • CAT Number: I001126
  • CAS Number: 1291074-87-7
  • Molecular Formula: C25H31N7O6
  • Molecular Weight: 525.56
  • Purity: ≥95%
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ENMD-2076 Tartrate (CAT: I001126) is a small-molecule kinase inhibitor with potential anti-cancer activity. It targets multiple kinases, including Aurora A, Flt3, VEGFR2, FGFR3, and Src, among others. ENMD-2076 exhibits inhibitory effects on angiogenesis and tumor growth in preclinical studies. It has shown activity against a wide range of cancer types, including ovarian, breast, colorectal, and multiple myeloma. ENMD-2076 has been investigated in clinical trials for various malignancies, both as a single agent and in combination with other therapies. It holds promise as a targeted therapeutic option for cancer treatment, particularly in patients with advanced or refractory disease.

Catalog Number I001126
CAS Number 1291074-87-7
Molecular Formula

C25H31N7O6

Purity 95%
Target Aurora Kinase
Solubility 10 mM in DMSO
Storage 3 years -20C powder
IC50 14 nM (Aurora A); 1.86 nM (Flt3); 58.2 nM (VEGFR2) [1]
Reference

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<br>[1]. Fletcher GC, et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37.

<br>[2]. Wang X, et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25.

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