Enalapril maleate

• CAT Number: I013878
• CAS Number: 76095-16-4
• Molecular Formula: C24H32N2O9
• Molecular Weight: 492.52
• Purity: ≥95%
• Synonyms: (Z)-but-2-enedioic acid;(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C20H28N2O5.C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25;5-3(6)1-2-4(7)8/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,16-,17-;/m0./s1
• InChIKey: OYFJQPXVCSSHAI-QFPUQLAESA-N
• SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CCCC2C(=O)O.C(=CC(=O)O)C(=O)O

Enalapril maleate (Cat No.: I013878) is an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension, heart failure, and asymptomatic left ventricular dysfunction. It works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby lowering blood pressure and reducing cardiac workload. Enalapril is a prodrug, converted in the liver to its active form, enalaprilat. Administered orally, it is generally well-tolerated. Common side effects include cough, dizziness, hyperkalemia, and fatigue. Rare but serious risks include angioedema and renal impairment.

Reference

[1]. Liu, Y.H., et al., Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice. J Cardiovasc Pharmacol, 2006. 47(1): p. 82-8.
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