SSE15206（Cat No.:I019767） is a microtubule polymerization inhibitor with a GI50 of 197 nM in HCT116 cells, which can overcome multidrug resistance. Causes incomplete spindle formation in cells, leading to G2/M arrest and abnormal mitosis.
| Catalog Number | I019767 |
| CAS Number | 1370046-40-4 |
| Molecular Formula | C₁₉H₂₁N₃O₃S |
| Purity | 95% |
| Storage | 2-8°C |
| IUPAC Name | 5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide |
| InChI | InChI=1S/C19H21N3O3S/c1-23-16-9-13(10-17(24-2)18(16)25-3)15-11-14(21-22(15)19(20)26)12-7-5-4-6-8-12/h4-10,15H,11H2,1-3H3,(H2,20,26) |
| InChIKey | GONIBFCARADPAC-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)C2CC(=NN2C(=S)N)C3=CC=CC=C3 |
| Reference | [1]. Manzoor S, et al. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 Feb 19;8(1):3305. |
