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SSE15206

SSE15206

  • CAT Number: I019767
  • CAS Number: 1370046-40-4
  • Molecular Formula: C₁₉H₂₁N₃O₃S
  • Molecular Weight: 371.45
  • Purity: ≥95%
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SSE15206（Cat No.:I019767） is a microtubule polymerization inhibitor with a GI50 of 197 nM in HCT116 cells, which can overcome multidrug resistance. Causes incomplete spindle formation in cells, leading to G2/M arrest and abnormal mitosis.

Catalog Number I019767
CAS Number 1370046-40-4
Molecular Formula

C₁₉H₂₁N₃O₃S

Purity 95%
Storage 2-8°C
IUPAC Name 5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide
InChI InChI=1S/C19H21N3O3S/c1-23-16-9-13(10-17(24-2)18(16)25-3)15-11-14(21-22(15)19(20)26)12-7-5-4-6-8-12/h4-10,15H,11H2,1-3H3,(H2,20,26)
InChIKey GONIBFCARADPAC-UHFFFAOYSA-N
SMILES COC1=CC(=CC(=C1OC)OC)C2CC(=NN2C(=S)N)C3=CC=CC=C3
Reference

[1]. Manzoor S, et al. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 Feb 19;8(1):3305.

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