Empagliflozin

• CAT Number: I005188
• CAS Number: 864070-44-0
• Molecular Formula: C₂₃H₂₇ClO₇
• Molecular Weight: 450.91
• Purity: ≥95%
• Target: SGLT
• Solubility: DMSO > 125 mg/ml
• Storage: 2-8°C
• IC50: 3.1 nM
• IUPAC Name: (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
• InChI: InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1
• InChIKey: OBWASQILIWPZMG-QZMOQZSNSA-N
• SMILES: C1COCC1OC2=CC=C(C=C2)CC3=C(C=CC(=C3)C4C(C(C(C(O4)CO)O)O)O)Cl

Empagliflozin（Cat No.:I005188）, a type 2 sodium-glucose cotransporter (SGLT-2, sodium-dependentglucosecotransporterChemicalbook2) inhibitor jointly developed by Boehringer Ingelheim and Eli Lilly and Company. SGLT-2 inhibitor is a new type of hypoglycemic drug, mainly by inhibiting the expression of SGLT-2, reducing the reabsorption of glucose by the kidneys, increasing the excretion of glucose in the urine, thereby reducing plasma glucose levels, and its hypoglycemic effect does not depend on in β-cell function and insulin resistance.

Reference

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