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Emixustat

Emixustat

  • CAT Number: I006659
  • CAS Number: 1141777-14-1
  • Molecular Formula: C16 H25 N O2
  • Molecular Weight: 263.38
  • Purity: ≥95%
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Emixustat(CAT: I006659) is a visual cycle modulator in development for the potential treatment of GA associated with dry AMD. Emixustat is a nonretinoid compound with a unique mode of action in the retinal pigment epithelium, where it modulates the biosynthesis of visual chromophore through its effect on retinal pigment epithelium-specific 65 kDa protein isomerase.

Catalog Number I006659
CAS Number 1141777-14-1
Molecular Formula

C16 H25 N O2

Purity 95%
Target visual cycle modulator
Storage -20°C
Related CAS 1141934-97-5(hydrochloride)
Reference

1: Dugel PU, Novack RL, Csaky KG, Richmond PP, Birch DG, Kubota R. Phase ii,
randomized, placebo-controlled, 90-day study of emixustat hydrochloride in
geographic atrophy associated with dry age-related macular degeneration. Retina.
2015 Jun;35(6):1173-83. doi: 10.1097/IAE.0000000000000606. PubMed PMID: 25932553;
PubMed Central PMCID: PMC4452434.

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2: Kubota R, Al-Fayoumi S, Mallikaarjun S, Patil S, Bavik C, Chandler JW. Phase
1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle
modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9. doi:
10.1097/01.iae.0000434565.80060.f8. PubMed PMID: 24056528.

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