Emixustat hydrochloride

• CAT Number: I000533
• CAS Number: 1141934-97-5
• Molecular Formula: C16H26ClNO2
• Molecular Weight: 299.839
• Purity: ≥95%
• Target: visual cycle modulator
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• Related CAS: 1141777-14-1 (free base).
• InChI: InChI=1S/C16H25NO2.ClH/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13;/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2;1H/t16-;/m1./s1
• InChIKey: BPZWRYOUJMDQSY-PKLMIRHRSA-N
• SMILES: O[C@@H](C1=CC=CC(OCC2CCCCC2)=C1)CCN.[H]Cl

Emixustat hydrochloride(cas 1141934-97-5) is a visual cycle modulator in development for the potential treatment of GA associated with dry AMD. Emixustat is a nonretinoid compound with a unique mode of action in the retinal pigment epithelium, where it modulates the biosynthesis of visual chromophore through its effect on retinal pigment epithelium-specific 65 kDa protein isomerase.

Reference

1: Dugel PU, Novack RL, Csaky KG, Richmond PP, Birch DG, Kubota R. Phase ii,
randomized, placebo-controlled, 90-day study of emixustat hydrochloride in
geographic atrophy associated with dry age-related macular degeneration. Retina.
2015 Jun;35(6):1173-83. doi: 10.1097/IAE.0000000000000606. PubMed PMID: 25932553;
PubMed Central PMCID: PMC4452434.

2: Kubota R, Al-Fayoumi S, Mallikaarjun S, Patil S, Bavik C, Chandler JW. Phase
1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle
modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9. doi:
10.1097/01.iae.0000434565.80060.f8. PubMed PMID: 24056528.