ELR-510444

• CAT Number: I000924
• CAS Number: 1233948-35-0
• Molecular Formula: C₁₉H₁₆N₂O₂S₂
• Molecular Weight: 368.5
• Purity: ≥95%
• Target: Microtubule/Tubulin
• Solubility: DMSO: ≥ 37 mg/mL
• Storage: Store at -20°C
• IC50: 30.9 nM(MDA-MB-231 cell) [1]
• IUPAC Name: N-[5-(5-cyanothiophen-2-yl)-2-methylphenyl]-4-methylbenzenesulfonamide
• InChI: InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3
• InChIKey: GRYXROIHHXHFND-UHFFFAOYSA-N
• SMILES: O=S(C1=CC=C(C)C=C1)(NC2=CC(C3=CC=C(C#N)S3)=CC=C2C)=O

ELR-510444 (Cat.No:I000924) is a novel chemical compound under investigation for its potential therapeutic applications. It exhibits inhibitory effects on certain enzymes involved in cellular processes. Further research is underway to explore its efficacy and safety profiles. Consultation with medical professionals is advised for accurate information and usage guidelines.

Reference

1:ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. Carew JS, Esquivel JA 2nd, Espitia CM, Schultes CM, Mülbaier M, Lewis JD, Janssen B, Giles FJ, Nawrocki ST.PLoS One. 2012;7(1):e31120. doi: 10.1371/journal.pone.0031120. Epub 2012 Jan 25. PMID: 22295124 Free PMC Article2:ELR510444, a novel microtubule disruptor with multiple mechanisms of action. Risinger AL, Westbrook CD, Encinas A, Mülbaier M, Schultes CM, Wawro S, Lewis JD, Janssen B, Giles FJ, Mooberry SL.J Pharmacol Exp Ther. 2011 Mar;336(3):652-60. doi: 10.1124/jpet.110.175331. Epub 2010 Dec 9. PMID: 21148249 Free PMC Article